60406-72-6Relevant academic research and scientific papers
A Convenient FeCl3-Mediated Synthesis of 5-Trifluoromethyl-1,2,4-triazoles from Trifluoroacetimidoyl Chlorides and Hydrazides
Du, Shiying,Wang, Le-Cheng,Yang, Zuguang,Chen, Zhengkai,Wu, Xiao-Feng
, p. 5130 - 5134 (2020)
A low cost FeCl3-mediated cascade annulation of trifluoroacetimidoyl chlorides and hydrazides for the efficient synthesis of 5-trifluoromethyl-1,2,4-triazoles has been developed. The transformation proceeds through a cascade base-promoted intermolecular C?N bond formation and FeCl3-mediated intramolecular dehydration sequence under mild conditions. The protocol exhibits many notable features and can be readily scaled up to gram scale. (Figure presented.).
Preparation method of 5-trifluoromethyl substituted 1, 2, 4-triazole derivative
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Paragraph 0034-0040, (2020/12/08)
The invention discloses a preparation method of a 5-trifluoromethyl substituted 1, 2, 4-triazole derivative. The preparation method comprises the following steps of adding sodium bicarbonate, a molecular sieve, trifluoroethyl imine acyl chloride and hydrazide into an organic solvent, and performing reacting at 30-50 DEG C for 8-16 hours to obtain the 5-trifluoromethyl substituted 1, 2, 4-triazolederivative; and adding metal lewis acid into a reaction system, continuing to perform reaction react at 70-90 DEG C for 6-10 hours, and after the reaction is completed, performing post-treatment to obtain the 5-trifluoromethyl substituted 1, 2, 4-triazole derivative. The preparation method is simple to operate, the initial raw materials are cheap and easy to obtain, the reaction does not need to be performed under anhydrous and anaerobic conditions, the 1, 2, 4-triazole derivative with trifluoromethyl groups and diversified substitutions at different positions can be synthesized through substrate design, the operation is convenient, and the applicability of the method is broadened.
Acaricidal trifluoromethyl-1,2,4-triazoles
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, (2008/06/13)
3-Trihalomethyl-1,2,4-triazoles either unsubstituted or having substituents in the 4 and/or 5, 1 and/or 5, and 2 and/or 5 positions; and methods for their preparation. Some of the compounds show biological activity; others have acaricidal activity.
