60418-49-7

Basic information

• Product Name: 8-chloro-2-methylpyrazoloquinoxaline
• CAS NO: 60418-49-7
• Molecular Weight: 217.658
• Mol File: 60418-49-7.mol

Chemical Properties

• CAS DataBase Reference: 8-chloro-2-methylpyrazoloquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-2-methylpyrazoloquinoxaline(60418-49-7)
• EPA Substance Registry System: 8-chloro-2-methylpyrazoloquinoxaline(60418-49-7)

Safety Data

• Hazardous Substances Data: 60418-49-7(Hazardous Substances Data)

Upstream product

• 60418-48-6 8-chloro-1,3-dimethyl-5H-pyrazolo<1,2-a>benzotriazol-4-ium inner salt 
• 60418-40-8 1-(2-azido-5-chlorophenyl)-3,5-dimethylpyrazole 
• 60418-33-9 1-(5-chloro-2-nitrophenyl)-3,5-dimethylpyrazole 

Relevant articles and documents

Chemistry of Nitrenes Generated by the Photocleavage of Both Azides and a Five-Membered Heterocycle

Pyrazolobenzotriazole and some of its derivatives (2a-c) are photochemically cleaved to form 2-(1-pyrazolyl)phenylnitrenes, which are also obtained through a more conventional path by photodecomposition of the pyrazolylphenyl azides (1a-c).Product

SYNTHESIS OF DIMETHYLPYRAZOLOBENZOTRIAZOLES AND OF METHYLPYRAZOLOQUINOXALINES BY CYCLIZATION OF 3,5-DIMETHYL-1-(2-NITRENOPHENYL)PYRAZOLES

The thermal and photochemical decomposition of a series of 5-substituted 1-(2-azidophenyl)-3,5-dimethylpyrazoles has been examined under a homogeneous set of conditions.Cyclization to pyrazolobenzotriazole (via singlet nitrene) is an efficient process except when the phenyl substituent induces intersystem crossing to the azide triplet or compensates for its electrophilicity.On the contrary, cyclization to pyrazoloquinoxaline (via triplet nitrene) is not a preparatively useful process, due to competition with dimerization to the azo derivatives and reduction to aminophenylpyrazoles.

Competitive Cyclisations of Singlet and Triplet Nitrenes. Part 8. The 1-(2-Nitrenophenyl)pyrazoles and Related Systems

The title nitrenes, derived by nitro-group deoxygenation with triethyl phosphite or by thermolysis or photolysis of the corresponding azide, have been studied.The effect of substituents (Cl, Br, OMe, NMe2, Me, CF3, and NO2) both meta and para to the nitrene has been examined as a determinant of the preferred mode of cyclisation to either a pyrazolobenzotriazole or a pyrazoloquinoxaline.Similarly, the role of solvents, sensitisers, and quenchers has been studied.Routes to the isomeric 1- and 2-(2-nitrophenyl)-4,5,6,7-tetrahydroindazoles have been defined and the literature corrected by studing the nitrene-mediated cyclisation of these products.The chemistry of the analogous 1-(2-carbenophenyl)- and the 1-(2-nitrenosulphonylphenyl)-3,5-dimethylpyrazoles has also been examined, the former giving 2-(3,5-dimethylpyrazol-1-yl)-benzaldazine and -benzyl alcohol while the latter gave products of intramolecular nitrene attack (a pyrazolobenzothiatriazine) and intermolecular reaction.Rationalisations for all the reaction pathways have been advanced.