60431-20-1Relevant academic research and scientific papers
A new entry to Pd-H chemistry: Catalytic asymmetric conjugate reduction of enones with EtOH and a highly enantioselective synthesis of warfarin
Tsuchiya, Yasunori,Hamashima, Yoshitaka,Sodeoka, Mikiko
, p. 4851 - 4854 (2007/10/03)
(Chemical Equation Presented) We report here the catalytic asymmetric conjugate reduction of enones using ethanol as a hydride source. The reaction was carried out in the presence of a chiral Pd complex at ambient temperature in ethanol, and the desired products were obtained in high chemical yield and high enantioselectivity. We applied this novel reaction to the catalytic asymmetric synthesis of warfarin (96% ee), and on the basis of d-labeling experiments, the reaction mechanism is proposed.
The first practical asymmetric synthesis of R and S-warfarin
Robinson, Andrea,Li, Hui-Yin,Feaster, John
, p. 8321 - 8324 (2007/10/03)
A highly efficient synthesis of both enantiomers of warfarin Ia and Ib has been developed by using a novel two step 'chiral switch' strategy and a DuPHOS-Rh(I) catalyzed asymmetric hydrogenation.
