60438-86-0

Upstream product

• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 106-42-3 para-xylene 

Downstream Products

• 60438-89-3 5-[4-(4-Carboxy-butyl)-2,5-dimethyl-phenyl]-pentanoic acid 
• 60438-90-6 5-[4-(4-Methoxycarbonyl-butyl)-2,5-dimethyl-phenyl]-pentanoic acid methyl ester 
• 60438-88-2 5-[4-(4-Methoxycarbonyl-butyl)-2,5-dimethyl-phenyl]-5-oxo-pentanoic acid methyl ester 
• 60438-87-1 5-(2,5-Dimethyl-phenyl)-pentanoic acid methyl ester 

Relevant academic research and scientific papers

FUSED TRICYCLIC BENZIMIDAZOLES DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of tricyclic benzimidazole derivatives, in particular dihydro-1H- imidazo [1,2-a]benzimidazo le, dihydro-1H-pyrrolo [1,2-a]benzimidazo le, dihydro-1H- pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.