60439-19-2Relevant academic research and scientific papers
Organocatalytic asymmetric reaction cascade to substituted cyclohexylamines
Zhou, Jian,List, Benjamin
, p. 7498 - 7499 (2008/02/10)
We report a new strategy for organocatalytic cascade reactions. Accordingly, enamine catalysis, iminium catalysis, and Bronsted acid catalysis can work in concert in a highly enantioselective organocatalytic cascade sequence toward chiral cis-3-substituted cyclohexylamines. We found that an achiral amine in combination with a catalytic amount of a chiral Bronsted acid can accomplish an aldol addition-dehydration-conjugate reduction-reductive amination to provide potential intermediates of pharmaceutically active compounds in good yields and excellent enantioselectivities. Copyright
