60445-13-8Relevant academic research and scientific papers
Synthesis and antimicrobial activity of some novel 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]- 1 H-benzimidazole derivatives
Kus, Canan,Soezuedoenmez, Fatma,Altanlar, Nurten
experimental part, p. 54 - 60 (2009/06/18)
In this study, we report the synthesis and antimicrobial evaluation of several new 4-(1H-benzimi-dazol-2-yl)benzamides (11 - 30) and 5-chloro-1-(p-fluorobenzyl)-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl} -1H-benzimidazole (33). Compound 20 exhibited the best antibacterial activity with MIC value of 6.25 μg/mL against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Significant antifungal activities were obtained with the compounds 13, 14, 18, 19, and 33 with MIC values of 3.12 μg/mL which are close to fluconazole.
