6045-08-5

Usage

Uses

Used in Pharmaceutical Syntheses:
2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6 is used as a common reagent in the pharmaceutical industry for the synthesis of various compounds. It plays a crucial role in the preparation of aminoBODIPY compounds, which are utilized for chemical analyses. 2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6 also aids in the synthesis of benzylurea-based insecticides containing amide and sulfonate groups, contributing to the development of new and effective pest control agents.
Used in Chemical Analyses:
In the field of chemical analyses, 2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6 is used for the preparation of aminoBODIPY compounds. These compounds are valuable for their fluorescent properties, which make them suitable for various analytical applications, including the detection and quantification of specific molecules in complex samples.
Used in Insecticide Synthesis:
2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6 is used as a reagent in the synthesis of benzylurea-based insecticides. These insecticides contain amide and sulfonate groups, which contribute to their effectiveness in controlling pests. 2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6's role in this process highlights its importance in the development of new and innovative pest control solutions.
Used in the Synthesis of Glutaminase Inhibitors:
2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6 has also been used in the synthesis of BPTES analogs, which act as glutaminase inhibitors. These inhibitors can attenuate the growth of human lymphoma B cells, making them a potential therapeutic option for cancer treatment. 2-AMINO-2-METHYL-D3-PROPANE-1,1,1,3,3,3-D6's involvement in the synthesis of these analogs underscores its significance in the development of novel cancer treatments.

InChI:InChI=1/C15H18N4O3/c1-4-5-14-13(10-17(2)3)15(20)18(16-14)11-6-8-12(9-7-11)19(21)22/h6-10H,4-5H2,1-3H3/b13-10-

Upstream product

• 25725-11-5 [D₉]-tert-butyl alcohol 

Downstream Products

• 52168-52-2 2-Methyl-2-nitropropane-d9 
• 1246819-04-4 D₉-cimbuterol 
• 1246819-58-8 D₉-mabuterol 
• 1184922-65-3 (R)-2-((tert-butyl-d9)amino)-1-(3-chlorophenyl)-2-d1-propan-1-one, deuterium chloride salt 

Relevant academic research and scientific papers

Electron Spin Resonance Spin-Trapping Analysis of γ-Induced Radicals in Polycrystalline α-D-Glucose

γ-Induced radicals in polycrystalline α-D-glucose are trapped with a water-ethanol solution of 2-nitroso-2-methylpropane.Five long-lived nitroxide spin-adducts are evidenced by electron spin resonance (ESR).Specifically labeled glucoses are also studied.Tentative assignments are discussed for each nitroxide radical.

A stable isotope labeled β receptor agonist synthetic method of compound

The invention relates to a synthesis method of a stable isotope-labeled beta receptor agonist type compound. The synthesis method comprises the following steps: (1) by taking stable isotope-labeled methanol as a raw material, reacting with acetone or stable isotope-labeled acetone, and ammonifying to obtain stable isotope-labeled tert-butylamine; and (2) by taking a bromoketone type compound as a precursor of the beta receptor agonist type compound, reacting with stable isotope-labeled tert-butylamine to prepare the stable isotope-labeled beta receptor agonist type compound. Compared with the prior art, the method for preparing the stable isotope-labeled beta receptor agonist, provided by the invention, is simple, safe and reliable, the chemical purity of the product after separation and purification is above 99.0%, the isotopic abundance is above 98.0% atom, and the product can fully meet the requirements of residual detection in the field of food safety.

Synthesis of stable isotope labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol

Three stable and simple synthetic routes of labeled D9-Mabuterol, D9-Bambuterol, and D9-Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to 1H NMR and liquid chromatography-tandem mass spectrometry.