60466-73-1Relevant academic research and scientific papers
Chiral hetero- and carbocyclic compounds from the asymmetric hydrogenation of cyclic alkenes
Verendel, J. Johan,Li, Jia-Qi,Quan, Xu,Peters, Byron,Zhou, Taigang,Gautun, Odd R.,Govender, Thavendran,Andersson, Pher G.
, p. 6507 - 6513 (2012/06/29)
Several types of chiral hetero- and carbocyclic compounds have been synthesized by using the asymmetric hydrogenation of cyclic alkenes. N,P-Ligated iridium catalysts reduced six-membered cyclic alkenes with various substituents and heterofunctionality in good to excellent enantioselectivity, whereas the reduction of five-membered cyclic alkenes was generally less selective, giving modest enantiomeric excesses. The stereoselectivity of the hydrogenation depended more strongly on the substrate structure for the five- rather than the six-membered cyclic alkenes. The major enantiomer formed in the reduction of six-membered alkenes could be predicted from a selectivity model and isomeric alkenes had complementary enantioselectivity, giving opposite optical isomers upon hydrogenation. The utility of the reaction was demonstrated by using it as a key step in the preparation of chiral 1,3-cis-cyclohexane carboxylates. Copyright
Stereochemical Assignments of the 7-Phenyl-3-oxabicycloheptanes
Corbin, Dale H.,Hobbs, Gregory D.,Woodyard, James D.
, p. 643 - 644 (2007/10/02)
A method for making stereochemical assignments based on nmr data for 7-phenyl-3-oxabicycloheptanes is described.
Stereochemical Assignments of the 7-Phenyl-2-oxabicycloheptanes
Woodyard, James D.,Morris, Paul R.,Hobbs, Gregory D.
, p. 1097 - 1099 (2007/10/02)
A rapid method for making stereochemical assignments based on variant temperature nmr data for the 7-phenyl-2-oxabicycloheptanes is described.
