60467-64-3

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 104-47-2 p-methoxybenzylnitrile 

Downstream Products

• 1312026-92-8 C₂₃H₂₃N₃O₂ 
• 477849-20-0 N-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-N'-[3-(4-methoxy-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 
• 477849-19-7 N-benzo[1,3]dioxol-5-ylmethylene-N'-[3-(4-methoxy-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 
• 477849-16-4 N-[1-(2,4-Dichloro-phenyl)-meth-(Z)-ylidene]-N'-[3-(4-methoxy-phenyl)-[1,8]naphthyridin-2-yl]-hydrazine 
• 477849-18-6 N-[3-(4-Methoxy-phenyl)-[1,8]naphthyridin-2-yl]-N'-[1-(3-nitro-phenyl)-meth-(Z)-ylidene]-hydrazine 

Relevant academic research and scientific papers

An Exceedingly Mild, Green Synthesis of Substituted N-3-diaryl-1,8-naphthyridin-2-amine Derivatives and Their Antimicrobial Activity

An exceedingly and highly efficient procedure has been described for the synthesis of substituted N-3-diaryl-1,8-naphthyridin-2-amines by the reaction of 2-chloro-3-aryl-1,8-naphthyridines with various anilines in the presence of N-methyl-2-pyrrolidone and K2CO3 under thermal green solvent-free conditions. The significant features of this green reaction include very good yields in purity, simple experimental, short reaction time, easy workability, and avoidance of toxic solvents. All synthesized compounds have been evaluated for their antibacterial activity.

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.

An exceedingly mild and efficient synthesis of 1,2,4-Triazolo[4,3-α][1,8]naphthyridines using iodobenzene diacetate in the solid state

An efficient and mild method for the synthesis of 1,2,4-triazolo[4,3-α][1,8]naphthyridines using iodobenzene diacetate (IBD) in the solid state at room temperature has been described. The reaction proceeds efficiently at room temperature in good yields and in a solid of high purity.