6047-29-6

Usage

Uses

Used in Pharmaceutical Industry:
5,6,11,12-TETRAHYDRODIBENZ[B,F]AZOCIN-6-ONE is used as a potential therapeutic agent for its anti-inflammatory and analgesic properties. Its identification in natural sources and demonstrated pharmacological activities make it a valuable compound for the development of new medications to treat various conditions that benefit from these properties.
Used in Research and Development:
In the field of scientific research, 5,6,11,12-TETRAHYDRODIBENZ[B,F]AZOCIN-6-ONE serves as an interesting target for further exploration. Its unique structure and potential biological activities are being investigated to uncover additional pharmacological applications, potentially leading to the discovery of novel treatments and therapies.

InChI:InChI=1/C15H13NO/c17-15-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)16-15/h1-8H,9-10H2,(H,16,17)

Upstream product

• 1021-91-6 N-[tricyclo[9.4.0.0^3,8]pentadeca-1⁽¹¹⁾,3,5,7,9,12,14-heptaen-2-ylidene]hydroxylamine 
• 2222-33-5 dibenzosuberenon 
• 1785-74-6 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one oxime 
• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 
• 833-48-7 dibenzosuberane 

Downstream Products

• 76011-97-7 2-<(11,12-dihydro-6-(5H)oxodibenzazocin-5-yl)methyl>benzoic acid 
• 252014-43-0 4'-(6-oxo-11,12-dihydro-6H-dibenzo[b,f]azocin-5-ylmethyl)-biphenyl-2-sulfonic acid amide 
• 136620-67-2 2-[2-(2-aminophenyl)ethyl]benzoic acid hydrochloride 
• 23194-93-6 2-azatricyclo[10.4.0.0^4,9]hexadeca-1⁽¹⁶⁾,4⁽⁹⁾,5,7,10,12,14-heptene 
• 1384870-47-6 1-{[6-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-6-oxohexanoyl]oxy}pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis

Strain-promoted azide–alkyne cycloaddition using dibenzoazacyclooctyne (DBCO) is widely applied in copper-free bioorthogonal reactions. Reported here is the efficient acid-promoted rearrangement and silver-catalyzed amidation of DBCO, which alters its click reactivity robustly. In the switched click reaction, DBCO, as a caged acylation reagent, enables rapid peptide/protein modification after decaging facilitated by silver catalysts, rendering site-specific conjugation of an IgG antibody by a Fc-targeting peptide.

Scalable synthesis of strained cyclooctyne derivatives

Modifications to the Popik synthesis of aza-dibenzocyclooctyne (DIBAC) derivatives are described, which avoids tedious purifications and dramatically improves the yield. A new and analogous route to biarylazacyclooctynone (BARAC) through an amide disconnection was also attempted. The BARAC derivatives prepared were found to be unstable under the conditions employed, undergoing a known rearrangement. Finally, the synthesis of a difluoro-DIBAC derivative with a second-order rate constant intermediate between DIBAC and BARAC derivatives (0.50 M-1) is described. While more difficult to synthesize, this molecule was found to be considerably more stable than any BARAC derivatives that were prepared. Georg Thieme Verlag Stuttgart New York.

Iron-catalyzed C-H and C-C bond cleavage: A direct approach to amides from simple hydrocarbons

Something functional: The title reaction proceeds in the presence of azide and water to deliver amides in high yields, and it can be used in a ring-expansion strategy to generate lactams. A mechanism is proposed based on experimental results. This reaction offers a new approach to functionalizing simple and readily available hydrocarbons. DDQ=2,3-dichloro-5,6-dicyano-1,4- benzoquinone. Copyright