604785-90-2

Upstream product

• 552879-97-7 tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol 
• 1012785-60-2 2,2-bis(benzyloxymethyl)-3-bromo-1-tert-butyldimethylsilyloxymethyl-3-fluorocyclopropane 

Downstream Products

• 1012785-64-6 2,2-bis(benzyloxymethyl)-3-fluoro-1-methylenecyclopropane 
• 1012785-65-7 2,2-bis(benzyloxymethyl)-1-bromo-1-bromomethyl-3-fluorocyclopropane 
• 1012785-67-9 (Z)-9-{[2,2-bis(benzyloxymethyl)-3-fluorocyclopropylidene]methyl}adenine 
• 1012785-66-8 (E)-9-{[2,2-bis(benzyloxymethyl)-3-fluorocyclopropylidene]methyl}adenine 
• 1012785-71-5 (Z)-2-amino-6-chloro-9-{[2,2-bis(benzyloxymethyl)-3-fluorocyclopropylidene]methyl}purine 
• 1012785-70-4 (E)-2-amino-6-chloro-9-{[2,2-bis(benzyloxymethyl)-3-fluorocyclopropylidene]methyl}purine 
• 1012785-63-5 C₂₆H₂₆NO₅FSe 
• 1012785-62-4 2,2-bis(benzyloxymethyl)-3-fluoro-1-(((2-nitrophenyl)selenyl)methyl)cyclopropane 

Relevant academic research and scientific papers

Fluoroanalogues of anti-cytomegalovirus agent cyclopropavir: Synthesis and antiviral activity of (E)- and (Z)-9-{[2,2-bis(hydroxymethyl)-3- fluorocyclopropylidene]methyl}-adenines and guanines

Synthesis of fluorinated cyclopropavir analogues 13a, 13b, 14a, and 14b is described starting from alkene 15. Addition of carbene derived from dibromofluoromethane gave bromofluoro cyclopropane 16. Reduction (compound 17) followed by desilylation gave int