604798-53-0

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 3-[[cyclopropyl(phenylmethyl)amino]methyl]-4-fluoro-, phenylmethyl ester, (3S,4S)-
• CAS NO: 604798-53-0
• Molecular Formula: C23H27FN2O2
• Molecular Weight: 382.478
• Mol File: 604798-53-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 3-[[cyclopropyl(phenylmethyl)amino]methyl]-4-fluoro-, phenylmethyl ester, (3S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 3-[[cyclopropyl(phenylmethyl)amino]methyl]-4-fluoro-, phenylmethyl ester, (3S,4S)-(604798-53-0)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 3-[[cyclopropyl(phenylmethyl)amino]methyl]-4-fluoro-, phenylmethyl ester, (3S,4S)-(604798-53-0)

Safety Data

• Hazardous Substances Data: 604798-53-0(Hazardous Substances Data)

Upstream product

• 949495-16-3 benzyl (3S,4R)-3-(N-benzyl-N-cyclopropyl)aminomethyl-4-hydroxypyrrolidine-1-carboxylate 
• 604798-52-9 (3S,4S)-3-benzylaminomethyl-1-benzyloxycarbonyl-4-fluoropyrrolidine 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 

Downstream Products

• 604798-54-1 (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrolidine 

Relevant articles and documents

METHOD FOR PRODUCING 3-SUBSTITUTED-4-FLUOROPYRROLIDINE DERIVATIVE

An inexpensive and industrially advantageous method for producing optically active syn-3-(N-substituted-aminomethyl)-4-fluoropyrrolidine which may be an intermediate for producing pharmaceuticals is provided. The present invention relates a method for pro

PROCESS FOR PRODUCTION OF 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION

An industrially advantageous process for the production of (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine or an enantiomer thereof that is useful as an intermediate for the production of novel antimicrobial agents 10-(3-cyclopropylaminomethyl-4-fluoropyrrolidinyl)pyridobenzox azine carboxylic acid derivatives. Highly stereoselective asymmetric hydrogenation of 1-protected-4-alkoxycarbonyl-3-oxopyrrolidine, followed by ester hydrolysis, followed by amidation with cyclopropylamine gives crude crystals. The crude crystals are purified by recrystallization to give a novel compound (3R,4S)-1-protected-3-cyclopropylcarbamoyl-4-hydroxypyrrolidin e or an enantiomer thereof at high optical purity. The use of these intermediates enables industrial production of high-quality products of (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine or an enantiomer thereof. The process is highly simple and can produce the desired products at high purity and stable yields.

10-(3-CYCLOPROPYLAMINOMETHYL-1-PYRROLIDINYL)PYRIDOBENZOXAZINECARBOXYLIC ACID DERIVATIVE EFFECTIVE AGAINST RESISTANT BACTERIUM

A compound as represented by the general formula (I) shown below exhibits high antibacterial activity against gram-positive bacteria, in particular, such drug-resistant bacteria as MRNA, PRSP and VRE: wherein R1 is a methyl group, a fluoromethyl group, a methoxymethyl group, an acetoxymethyl group, a hydroxymethyl group or a methylene; R2 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, or a pharmaceutically acceptable cation and an ester of a prodrug; R3 is a hydrogen atom or a halogen atom; R4 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, a fluoromethyl group, a trifluoromethyl group or a fluorine atom; and R5 is a hydrogen atom or a fluorine atom, with exceptions where R1 is a methyl group, R4 and R5 are at the same time a hydrogen atom, and R3 is a fluorine atom.