604798-71-2

Basic information

• Product Name: 3-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4R)-(9CI)
• Synonyms: 3-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4R)-(9CI)
• CAS NO: 604798-71-2
• Molecular Formula: C8H15FN2
• Molecular Weight: 158.22
• Product Categories: HALIDE
• Mol File: 604798-71-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 232.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• PKA: 8.55±0.20(Predicted)
• CAS DataBase Reference: 3-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4R)-(9CI)(604798-71-2)
• EPA Substance Registry System: 3-Pyrrolidinemethanamine,N-cyclopropyl-4-fluoro-,(3R,4R)-(9CI)(604798-71-2)

Safety Data

• Hazardous Substances Data: 604798-71-2(Hazardous Substances Data)

Upstream product

• 604798-70-1 (3S,4R)-3-(N-benzyl-N-cyclopropyl)aminomethyl-1-benzyloxycarbonyl-4-fluoropyrrolidine 

Relevant articles and documents

Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4] benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl- 4-substituted-1-pyrrolidinyl group as a C-10 substituent

Novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives 5-9 carrying a 3-cyclopropylami-nomethyl-4-substituted-1-pyrrolidinyl moiety at the C-10 position were synthesized and their in vitro antibacterial activity, intravenous single-dose toxi

10-(3-CYCLOPROPYLAMINOMETHYL-1-PYRROLIDINYL)PYRIDOBENZOXAZINECARBOXYLIC ACID DERIVATIVE EFFECTIVE AGAINST RESISTANT BACTERIUM

A compound as represented by the general formula (I) shown below exhibits high antibacterial activity against gram-positive bacteria, in particular, such drug-resistant bacteria as MRNA, PRSP and VRE: wherein R1 is a methyl group, a fluoromethyl group, a methoxymethyl group, an acetoxymethyl group, a hydroxymethyl group or a methylene; R2 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, or a pharmaceutically acceptable cation and an ester of a prodrug; R3 is a hydrogen atom or a halogen atom; R4 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms, a fluoromethyl group, a trifluoromethyl group or a fluorine atom; and R5 is a hydrogen atom or a fluorine atom, with exceptions where R1 is a methyl group, R4 and R5 are at the same time a hydrogen atom, and R3 is a fluorine atom.