604799-96-4

Basic information

• Product Name: 1-(2-BROMOPHENYL)CYCLOPROPANAMINE
• Synonyms: 1-(2-BROMO-PHENYL)-CYCLOPROPYLAMINE;1-(2-BROMOPHENYL)CYCLOPROPANAMINE;Cyclopropanamine, 1-(2-bromophenyl)-;1-(2-Bromophenyl)cyclopropan-1-amine
• CAS NO: 604799-96-4
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 212.09
• EINECS: 604-604-1
• Mol File: 604799-96-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 272.817°C at 760 mmHg
• Flash Point: 118.796°C
• Appearance: /
• Density: 1.519g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(2-BROMOPHENYL)CYCLOPROPANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOPHENYL)CYCLOPROPANAMINE(604799-96-4)
• EPA Substance Registry System: 1-(2-BROMOPHENYL)CYCLOPROPANAMINE(604799-96-4)

Safety Data

• Hazardous Substances Data: 604799-96-4(Hazardous Substances Data)

Usage

General Description

1-(2-Bromophenyl)cyclopropanamine is a chemical compound with the molecular formula C9H10BrN. It is a cyclopropane-based amine derivative with a bromophenyl group attached to the cyclopropane ring. 1-(2-BROMOPHENYL)CYCLOPROPANAMINE is potentially useful in the synthesis of pharmaceuticals and organic compounds due to its unique structure and functional groups. It may also possess biological activity and could potentially be used in medicinal chemistry research. However, further studies are needed to fully understand its properties and potential applications.

InChI:InChI=1/C9H10BrN/c10-8-4-2-1-3-7(8)9(11)5-6-9/h1-4H,5-6,11H2

Upstream product

• 2042-37-7 o-cyanobromobenzene 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 1021539-30-9 (4aS,5R)-5-(2-(1-aminocyclopropylphenyl)ethynyl)-1-(4-fluorophenyl)-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-ol 

Relevant articles and documents

Ligand Optimization by Improving Shape Complementarity at a Hepatitis C Virus RNA Target

Crystal structure analysis revealed key interactions of a 2-amino-benzimidazole viral translation inhibitor that captures an elongated conformation of an RNA switch target in the internal ribosome entry site (IRES) of hepatitis C virus (HCV). Here, we have designed and synthesized quinazoline derivatives with improved shape complementarity at the ligand binding site of the viral RNA target. A spiro-cyclopropyl modification aimed at filling a pocket in the back of the RNA binding site led to a 5-fold increase of ligand affinity while a slightly more voluminous dimethyl substitution at the same position did not improve binding. We demonstrate that precise shape complementarity based solely on hydrophobic interactions contributes significantly to ligand binding even at a hydrophilic RNA target site such as the HCV IRES conformational switch.

2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS

The present invention is directed to 2- [l-phenyl-5 -hydroxy or methoxy-4alpha- methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives of formula I (I) as glucocorticoid receptor ligands useful for treating a variety of autoimmune and inflamma