60505-19-3Relevant academic research and scientific papers
Synthesis of some benzofurooxepines' derivatives via [3+2] cycloaddition of epoxide with tethered alkyne: A photochemical approach
Kamboj, Ramesh C.,Jindal, Pooja,Kumar, Dinesh,Khullar, Sadhika,Mandal, Sanjay K.
, p. 31 - 38 (2014)
A novel, environmentally benign and single-step synthesis of 8-chloro-2-arylbenzo[b]furo[2,3-e]oxepin-10(4H)-ones by the photochemical irradiation of 2-{5-chloro-2-(prop-2-ynyloxy)benzoyl}-3-aryloxiranes has been developed. Some of these substrates also f
Design and synthesis of new 1,2,3-triazole-pyrazole hybrids as antimicrobial agents
Pervaram,Ashok,Rao,Sarasija,Reddy
, p. 2454 - 2461 (2017/11/24)
In the present study, a series of novel 1,2,3-triazoles derivatives (4a–4c) were synthesized by the 1,3-dipolar cycloaddition (click-reaction) of 1-phenyl-3-[2-(prop-2-yn-1-yloxy)phenyl substituted]-1H-pyrazole-4-carbaldehyade (3a–3c) with various aryl az
1,2,3-Triazole tethered acetophenones: Synthesis, bioevaluation and molecular docking study
Shaikh, Mubarak H.,Subhedar, Dnyaneshwar D.,Khedkar, Vijay M.,Jha, Prakash C.,Khan, Firoz A. Kalam,Sangshetti, Jaiprakash N.,Shingate, Bapurao B.
, p. 1058 - 1063 (2016/07/29)
A small focused library of eighteen new 1,2,3-triazole tethered acetophenones has been efficiently prepared via click chemistry approach and evaluated for their antifungal and antioxidant activity. The antifungal activity was evaluated against five human pathogenic fungal strains: Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger, and Cryptococcus neoformans. Among the synthesized compounds, 9c, 9i, and 9p found to be more potent antifungal agents that the reference standard. These 1,2,3-triazole based derivatives were also evaluated for antioxidant activity, and compound 9h was found to be the most potent antioxidant as compared to the standard drug. Furthermore, molecular docking study of the newly synthesized compounds was performed and results showed good binding mode in the active site of fungal C. albicans enzyme P450 cytochrome lanosterol 14α-demethylase. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential as good oral drug candidates.
Photochemistry of aroyloxiranes: Substituent effect on oxepinones and hydroxyalkenones formation
Dalal, Aarti,Khanna, Radhika,Berar, Urmila,Kamboj, Ramesh C.
, p. 238 - 245 (2016/07/22)
The photo-irradiation of some aroyloxiranes with Pyrex filtered UV-light from 125?W medium pressure Hg lamp has been described. These compounds furnished the 2-aryl-4,10-dihydrofuro[3,2-c][1]benzoxepin-10-ones and the hydroxyalkenones by the photochemical irradiation. The product(s) formation/distribution in terms of oxepinones and the hydroxyalkenones largely depended upon the nature of the substituent: the oxiranes having electron-donating groups in their benzoyl moiety gave the hydroxyalkenones while oxiranes having electron-withdrawing groups furnished the oxepinones as the major products. The formation of oxepinones has been envisaged to occur through the heterolytic [Formula presented] bond cleavage of epoxide to give carbonyl ylide intermediates followed by the furo-oxepinone ring formation via [3+2] cycloaddition and of hydroxyalkenones through the initial β-H abstraction followed by epoxide ring opening. The structures of all the compounds (substrates and photoproducts) have been determined on the basis of their spectral data (IR, NMR and Mass).
A domino synthetic approach for new, angular pyrazol- and isoxazol-heterocycles using [DBU][Ac] as an effective reaction medium
Sutariya, Tushar R.,Labana, Balvantsingh M.,Parmar, Bhagyashri D.,Parmar, Narsidas J.,Kant, Rajni,Gupta, Vivek K.
, p. 23519 - 23529 (2015/04/14)
O-Cinnamyloxy/geranyloxy/cyclohexenyloxy/cinnamoyloxy-acetophenones yielded pyrazol-heterocycles, all of which contained an angular methyl-attached pyranopyran unit with pyrazolones in the ionic liquid (IL), 1,8-diazabicyclo[5.4.0]undec-7-ene-8-ium acetat
Unprecedented synthesis of aza-bridged benzodioxepine derivatives through a tandem Rh(ii)-catalyzed 1,3-rearrangement/[3+2] cycloaddition of carbonyltriazoles
Zhang, Yong-Sheng,Tang, Xiang-Ying,Shi, Min
supporting information, p. 15971 - 15974 (2015/01/08)
Rh(ii)-catalyzed novel tandem intramolecular cycloisomerizations of aldehydes or ketones with 1-sulfonyl 1,2,3-triazoles have been disclosed, providing a facile protocol to access a series of functionalized aza-bridged benzodioxepine heterocycles.
Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases
Srinivasan, Rajavel,Uttamchandani, Mahesh,Yao, Shao Q.
, p. 713 - 716 (2007/10/03)
We have successfully designed and synthesized a small library of protein tyrosine phosphatase (PTP) inhibitors, in which the so-called "click chemistry" or Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction was carried out for rapid assembly of 66 different bidentate compounds. Subsequent in situ enzymatic screening revealed a potential PTP1B inhibitor (IC50 = 4.7 μM) which is 10-100 fold more potent than other PTPs.
