6051-02-1

Basic information

• Product Name: (5Z)-3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one
• Synonyms: (5Z)-3-(4-Fluorophenyl)-5-(1H-indol-3-ylmethylene)-2-thioxo-1,3-thiazolidin-4-one; 4-Thiazolidinone, 3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylene)-2-thioxo-, (5Z)-
• CAS NO: 6051-02-1
• Molecular Formula: C₁₈H₁₁FN₂OS₂
• Molecular Weight: 354.4211
• Mol File: 6051-02-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 567.4°C at 760 mmHg
• Flash Point: 297°C
• Density: 1.53g/cm³
• Vapor Pressure: 6.84E-13mmHg at 25°C
• Refractive Index: 1.797
• CAS DataBase Reference: (5Z)-3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z)-3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(6051-02-1)
• EPA Substance Registry System: (5Z)-3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one(6051-02-1)

Safety Data

• Hazardous Substances Data: 6051-02-1(Hazardous Substances Data)

Usage

General Description

The chemical compound "(5Z)-3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one" is a thiazolidinone derivative with a molecular structure containing a thiazolidine ring and an indole ring. It is a potent inhibitor of dipeptidyl peptidase-4 (DPP-4), a key enzyme involved in the regulation of glucose metabolism. (5Z)-3-(4-fluorophenyl)-5-(1H-indol-3-ylmethylidene)-2-thioxo-1,3-thiazolidin-4-one has potential therapeutic applications in the treatment of type 2 diabetes, as it can improve glycemic control by increasing insulin secretion and reducing glucagon levels. Additionally, its fluoro substituent enhances its bioavailability and metabolic stability. This chemical has generated interest in the pharmaceutical industry as a promising candidate for the development of new anti-diabetic drugs.