6051-08-7

Basic information

• Product Name: 3-oxaspiro[5.5]undecan-2-one
• CAS NO: 6051-08-7
• Molecular Formula: C₁₀H₁₆O₂
• Molecular Weight: 168.2328
• Mol File: 6051-08-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 273.2°C at 760 mmHg
• Flash Point: 109°C
• Density: 1.04g/cm³
• Vapor Pressure: 0.00581mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: 3-oxaspiro[5.5]undecan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxaspiro[5.5]undecan-2-one(6051-08-7)
• EPA Substance Registry System: 3-oxaspiro[5.5]undecan-2-one(6051-08-7)

Safety Data

• Hazardous Substances Data: 6051-08-7(Hazardous Substances Data)

Upstream product

• 1010-26-0 1,1-cyclohexanediacetic acid anhydride 
• 3187-27-7 2,2'-(cyclohexane-1,1-diyl)bis(ethan-1-ol) 

Downstream Products

• 518284-95-2 1-(2-Bromoethyl)cyclohexylacetic acid 
• 4355-11-7 1,1-cyclohexanediacetic acid 

Relevant articles and documents

Catalytic Asymmetric Synthesis of Cyclohexanes by Hydrogen Borrowing Annulations

Hydrogen borrowing catalysis serves as a powerful alternative to enolate alkylation, enabling the direct coupling of ketones with unactivated alcohols. However, to date, methods that enable control over the absolute stereochemical outcome of such a process have remained elusive. Here we report a catalytic asymmetric method for the synthesis of enantioenriched cyclohexanes from 1,5-diols via hydrogen borrowing catalysis. This reaction is mediated by the addition of a chiral iridium(I) complex, which is able to impart high levels of enantioselectivity upon the process. A series of enantioenriched cyclohexanes have been prepared and the mode of enantioinduction has been probed by a combination of experimental and DFT studies.

NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME,PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N-R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like.The 4-(2-furoyl) aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.