6052-74-0Relevant articles and documents
SYNTHESIS AND MOLECULAR STRUCTURE OF PIPLARTINE (=PIPERLONGUMINE)
Boll, Per M.,Hansen, Jesper,Simonsen, Ole,Thorup, Niels
, p. 171 - 176 (2007/10/02)
The structure of piplartine (=piperlongumine) was established as (E)-N-3',4',5'-trimethoxycinnamoyl-5,6-dihydro-2(1H)-pyridone (13) by synthesis and by an X-ray crystallographic analysis.Model condensation of (E)-3,4,5-trimethoxycinnamoyl chloride and crotonamide gave not the expected ciannamoylcrotonamide, but (E)-N-3',4',5'-trimethoxycinnamoyl-3-chlorobutyramide (12).