60520-17-4Relevant academic research and scientific papers
A simple method to generate [18F]triflyl fluoride for 18F radiosynthesis
Katzenellenbogen, John A.,Zhou, Dong
supporting information, (2021/07/25)
A simple, continuous-flow solid-phase radiosynthesis method has been developed for the generation of [18F]triflyl fluoride as a source of [18F]fluoride for the preparation of 18F labeled radiopharmaceuticals without the ne
SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE
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Paragraph 0076, (2018/01/11)
The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl c
Synthesis of [18F]fluoro-pivalic acid: An improved PET imaging probe for the fatty acid synthesis pathway in tumours
Pisaneschi, Federica,Witney, Timothy H.,Iddon, Lisa,Aboagye, Eric O.
, p. 1350 - 1353 (2013/10/08)
[18F]Fluoro-pivalic acid ([18F]FPIA), an analogue of [18F]fluoroacetate bearing a dimethyl moiety on C-2, has been radiosynthesised and evaluated in vivo. [18F]FPIA has high tumour uptake and, unlike [18/s
Automated synthesis and purification of [18F]fluoro-[di-deutero] methyl tosylate
Beyerlein, Friederike,Piel, Markus,Hoehnemann, Sabine,Roesch, Frank
, p. 360 - 363 (2013/07/26)
Automated synthetic procedures of [18F]fluoro-[di-deutero]methyl tosylate on a GE TRACERlab FX F-N module and a non-commercial synthesis module have been developed. The syntheses included azeotropic drying of the [ 18F]fluoride, nucleophilic 18F-fluorination of bis(tosyloxy)-[di-deutero]methane, HPLC purification and subsequent formulation of the synthesized [18F]fluoro-[di-deutero]methyl tosylate (d 2-[18F]FMT) in organic solvents. Automation shortened the total synthesis time to 50 min, resulting in an average radiochemical yield of about 50% and high radiochemical purity (>98%). The possible application of this procedure to commercially available synthesis modules might be of significance for the production of deuterated 18F-fluoromethylated imaging probes in the future. Copyright
Sulfonyl fluoride-based prosthetic compounds as potential 18F labelling agents
Inkster, James A. H.,Liu, Kate,Ait-Mohand, Samia,Schaffer, Paul,Guérin, Brigitte,Ruth, Thomas J.,Storr, Tim
, p. 11079 - 11087 (2012/09/22)
Nucleophilic incorporation of [18F]F- under aqueous conditions holds several advantages in radiopharmaceutical development, especially with the advent of complex biological pharmacophores. Sulfonyl fluorides can be prepared in water
Improved synthesis of [18F]fluoromethyl tosylate, a convenient reagent for radiofluoromethylations
Neal, Timothy R.,Apana, Scott,Berridge, Marc S.
, p. 557 - 568 (2007/10/03)
The utility of [18F]fluoromethyl tosylate as an [ 18F]fluoromethylation reagent has been reexamined. The preparation of this potentially useful compound from the reaction of bis(tosyloxy) methane with 18F- was reported sev
