60521-70-2Relevant academic research and scientific papers
Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates
Koniev, Oleksandr,Dovgan, Igor,Renoux, Brigitte,Ehkirch, Anthony,Eberova, Jitka,Cianférani, Sarah,Kolodych, Sergii,Papot, Sébastien,Wagner, Alain
supporting information, p. 827 - 830 (2018/05/31)
The reduction-rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody-drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebri
3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING
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Paragraph 0172-0173; 0297-0298, (2016/06/13)
The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.
Transition Metal-Free Approach to Propynenitriles and 3-Chloropropenenitriles
Sharma, Pawan K.,Ram, Sita,Chandak, Navneet
supporting information, p. 894 - 899 (2016/04/05)
A transition metal-free, facile and efficient one-pot protocol for the synthesis of propynenitriles from readily available 3-chloropropenals is disclosed. The reaction conditions have also been optimized for the exclusive formation and isolation of 3-chloropropenenitriles which are important building blocks in general and are intermediates in the synthesis of propynenitriles. The hallmark of the methodology is the use of non-toxic reagents, milder, metal-free and economically benign reaction conditions avoiding a harsh dehydration step while achieving excellent yields.
