60522-10-3

Upstream product

• 17360-25-7 N-(p-toluenesulfonyl)-L-valine 
• 74-88-4 methyl iodide 
• 98-59-9 p-toluenesulfonyl chloride 
• 72-18-4 L-valine 
• 60522-08-9 tert-butyl 3-methyl-2-(4-methylphenylsulfonamido)butanoate 
• 6306-52-1 L-valine methylester hydrochloride 
• 82333-02-6 N-p-Toluolsulfonyl-L-valin-methylester 
• 51220-85-0 Methyl (S)-N-<(4-methylphenyl)sulfonyl>valinate 
• 78797-29-2 (S)-4-isopropyl-3-tosyl-1,3-oxazolidin-5-one 
• 158038-79-0 Tos(Me)-Val-OBzl 
• 158038-81-4 (R)-Tos(Me)-Val-OBzl 
• 158038-66-5 Tos(Me)-Val-OMe 
• 60522-09-0 (S)-3-Methyl-2-[methyl-(toluene-4-sulfonyl)-amino]-butyric acid tert-butyl ester 

Downstream Products

• 512167-59-8 (S)-N,N-diisopropyl-3-methyl-2-(N-methyl-N-tosylamino)butanamide 

Relevant academic research and scientific papers

Synthesis and pharmacological profile of 6-methyl-3-isopropyl-2H-1,2-benzothiazin-4(3H)-one 1,1-dioxide derivatives: Non-steroidal anti-inflammatory agents with reduced ulcerogenic effects in the rat

The new anti-inflammatory agents 6-methyl-3-isopropyl-2H-1,2-benzothiazin-4(3H)-one 1,1-dioxide 6a and its analogues 6b-f were synthesized from L-valine. All compounds were characterized by physical, chemical and spectral studies. Preliminary pharmacologi

A simple and rapid protocol for N-methyl-α-amino acids

A two step strategy for optically pure N-Protected-N-methyl-α-amino acids starting from N-protected-α-amino acids via reductive cleavage of oxazolidinones using NaCNBH3/TMSCl is described.

Redox N-Alkylation of Tosyl Protected Amino Acid and Peptide Esters

Condensation of Nα-tosylated amino acid and peptide esters with alcohols (MeOH, EtOH, iPrOH) in the presence of the triphenylphosphine-diethyl azodicarboxylate adduct produced excellent yields of the corresponding Nα-alkyl

AN ALTERNATIVE ROUTE TO Nα-METHYLAMINO ACID DERIVATIVES: SYNTHESIS AND CONFORMATION OF SOME Nα-acetyl-Nα-METHYLAMINO ACID METHYLAMIDES

The methylation of tert-butyl- or isopropyl esters of Nα-4-toluenesulfonyl-amino acids by dimethylsulfate in aqueous alkaline solution in the presence of a detergent gives the corresponding Nα-methylderivatives.Using this synthetic route the Nα-acetylderivatives of MeAla, MeLeu, MeOrn and MePhe methylamides have been prepared and the solution conformation of these dipeptide units has been investigated. 1H and 13C NMR spectra show that, while in dimethylsulfoxide the tertiary amide group is mostly in cis-conformation, in protic solvents the equilibrium is shifted towards trans-conformation.Circular dichroism spectra reveal some specific features (e.g. high band intensities in protic solvents) which cannot be explained solely on the basis of the increased rigidity caused by the Nα-methyl group.We tried to explain these effects supposing that the tertiary amide group is deviated from the planar arrangement (due to the interaction between the methyl groups, a substituent on Cα and solvent molecule attached to the oxygen atom) and contributes to the observed circular dichroism as the inherently chiral chromophore.