60526-86-5

Upstream product

• 768-95-6 1-adamanthanol 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 60526-74-1 4-(adamantan-1-yl)-2,6-dimethoxyphenol 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 60526-80-9 4-(adamantan-1-yl)-2,6-dimethoxyphenyl diethyl phosphate 

Downstream Products

• 1313053-08-5 3-(adamantan-1-yl)-4-bromo-5-methoxyphenol 
• 1434116-97-8 4′-(adamantan-1-yl)-N,N-diisopropyl-2′,5,6′-trimethoxy-[1,1′-biphenyl]-2-carboxamide 
• 1434116-94-5 5-(1-adamantyl)-2-bromo-1,3-dimethoxybenzene 
• 60526-91-2 5-(1-adamantanyl)resorcinol 

Relevant academic research and scientific papers

Selective ortho-Functionalization of Adamantylarenes Enabled by Dispersion and an Air-Stable Palladium(I) Dimer

Contrary to the general belief that Pd-catalyzed cross-coupling at sites of severe steric hindrance are disfavored, we herein show that the oxidative addition to C?Br ortho to an adamantyl group is as favored as the corresponding adamantyl-free system due

Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate

The generation of tertiary, secondary, and primary alkyl radicals has been achieved by the direct visible-light excitation of a boracene-based alkylborate. This system is based on the photophysical properties of the organoboron molecule. The protocol is applicable to decyanoalkylation, Giese addition, and nickel-catalyzed carbon-carbon bond formations such as alkyl-aryl cross-coupling or vicinal alkylarylation of alkenes, enabling the introduction of various C(sp3) fragments to organic molecules.

Synthesis of functionalized cannabilactones

A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.

Adamantyl cannabinoids: A novel class of cannabinergic ligands

Structure-activity relationship studies have established that the aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We have now synthesized a series of analogues in which a variety of a

5-(Tertiary alkyl) resorcinol preparation and intermediates therefor

2,6-Dimethoxyphenol reacts with a tertiary carbinol in the presence of an acid to provide exclusively a 1-hydroxy-2,6-dimethoxy-4-tertiary alkyl)benzene, which when reacted with a halogenated disubstituted phosphite affords a 2,6-dimethoxy-4-tertiary alkyl)phenyl disubstituted phosphate. Reduction of the phenyl phosphate derivative by reaction with an alkali metal affords a 1-(tertiary alkyl)-3,5-dimethoxybenzene, which upon reaction with a demethylating agent provides a 5-(tertiary alkyl)resorcinol.