6053-00-5

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General Description

1,2-Benzenediol,4-[[[2-(4-hydroxyphenyl)ethyl]- amino]methyl]- is a chemical compound with a complex structure that includes a benzene ring along with hydroxyl and amino groups. The compound is also known as 4-((2-(4-hydroxyphenyl)ethyl)amino)methyl)benzene-1,2-diol and is a derivative of catechol. It is used in the pharmaceutical industry as a building block for the synthesis of various drugs and as a reagent in chemical reactions. The compound has potential applications in the treatment of various medical conditions and may also exhibit antioxidant properties. However, further research is needed to fully understand and harness the potential benefits of this chemical.

Upstream product

• 51-67-2 tyrosamine 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 51179-05-6 2-(4-(benzyloxy)phenyl)ethanamine 
• 838-96-0 2-[4-(benzyloxy)phenyl]acetonitrile 
• 836-43-1 4-benzyloxybenzyl alcohol 
• 836-42-0 4-benzyloxybenzyl chloride 

Relevant academic research and scientific papers

Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as an anti-inflammatory/anti-COX compound

Rising ROS and systemic inflammation is often a serious concern in many disease conditions including obesity. Therefore, compounds with both anti-oxidant and anti-inflammatory activities are considered beneficial in preventing/treating several human chronic diseases. Norbelladine is an amine compound, a precursor for Amaryllidaceae alkaloids (e.g., belladine, crinamine, lycorine, and galanthamine) found in plants traditionally used for treating a variety of human diseases. However, little information is available about its potential health effects. Therefore, the amine was first synthesized, and its anti-oxidant and anti-inflammatory activities were investigated in this study. Also, the potential effects of the amine on NF-κB activation were investigated due to the critical involvement of ROS in the activation. Norbelladine was synthesized with more than 60% yield, analyzed by a HPLC method, and verified using NMR spectroscopic method. Then, its radical scavenging activity was investigated using DPPH- and superoxide radical assays. At the concentration of 10 μM, norbelladine was a compound able to quench DPPH-radical by 31% (P a compound to quench radicals, inhibit COX enzymes as well as suppress NF-κB activation at relatively lower concentrations.

CONSTRUCTS AND METHODS FOR BIOSYNTHESIS OF GALANTHAMINE

The present disclosure relates generally to the identification of enzymes within the Amaryllidaceae alkaloid biosynthetic pathway as well as to engineering transgenic organisms for the production of galanthamine and/or hemanthamine and/or lycorine. Disclosed herein is the isolation and characterization of cDNAs and encoded norbelladine 4'-0-methyltransferase, CYP96T1-3, and norbelladine synthase/reductase involved in the biosynthesis of galanthamine and haemanthamine. The invention relates to a transgenic plant, comprising within its genome, and expressing, a heterologous nucleotide sequence coding for a class I O-methyltransferase, wherein the O-methyltransferase is norbelladine 4'-0-methyltransferase. In one embodiment, the norbelladine 4'-0-methyltransferase is selected from among NpN40MT1, NpN40MT2, NpN40MT3, NpN40MT4, and NpN40MT5. The invention further contemplates a method of making a transgenic plant.

A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase

9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy

ABSCISIC ACID BIOSYNTHESIS INHIBITOR

Compounds represented by the following general formula (I) or salts thereof: wherein R1 represents hydrogen atom, hydroxyl group, or an alkoxy group; R2 represents hydroxyl group or an alkoxy group which may be substituted; R3/