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6054-98-4

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Olsalazine Sodium
Cas No: 6054-98-4
No Data No Data Metric Ton/Day Shanghai Yanchu chemicals Co., Ltd Contact Supplier
Olsalazine disodium
Cas No: 6054-98-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Olsalazine Sodium supplier in China
Cas No: 6054-98-4
No Data No Data Metric Ton/Day Simagchem Corporation Contact Supplier
High Quality 99% Olsalazine sodium 6054-98-4 GMP manufacturer
Cas No: 6054-98-4
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Factory Supply Olsalazine Sodium
Cas No: 6054-98-4
No Data 1 1 Ality Chemical Corporation Contact Supplier
Olsalazine disodium
Cas No: 6054-98-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Mordant yellow 5 sodium salt (C.I. 14130)
Cas No: 6054-98-4
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Pharmaceutical Grade CAS 6054-98-4 with competitive price
Cas No: 6054-98-4
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
BLOOM TECH Advanced API/Technology support Olsalazine Sodium CAS 6054-98-4
Cas No: 6054-98-4
No Data 1 Gram 3 Metric Ton/Month Shaanxi BLOOM TECH Co.,Ltd Contact Supplier
Olsalazine disodium/ LIDE PHARMA- Factory supply / Best price
Cas No: 6054-98-4
No Data No Data 1 LIDE PHARMACEUTICALS LIMITED Contact Supplier

6054-98-4 Usage

Uses

Dimer of Mesalazine (M258100), an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis.

Chemical Properties

Yellow Crystalline Powder

Brand name

Dipentum (UCB).

Adverse reaction

The most common side effect is diarrhoea, the incidence of which is 17%. Usually, the difference between diarrhea and intestinal inflammation is that the excreta has high water content without blood, and is related to the dosage. It usually occurs when the treatment begins or the dose increases. Reduction the dose of this product or combined use with Loperamide, diarrhea will be controlled. Other side effects include headache, nausea, abdominal pain, rash, dizziness and joint pain. Most of the patients who are allergic or intolerant to sulfasalazine are resistant to this product. The male sterility treated with sulfasalazine improved after using this product.

Uses

Mordant dye for wool.

Treatment of acute and chronic colitis

Olsalazine sodium is a drug developed by Pharmacia A B Co., Switzerland, to treat acute and chronic colitis. It was first listed in Denmark in 1989. It has been collected and recordedby the European Pharmacopoeia 7 edition and the national drug standard WS1(X-349) -2004Z. Orsalazine sodium is a precursor drug consisting of two azo bonds linked to 5amino salicylic acid. The bacteria in the colon break up the diazo bond and release 5amino salicylic acid. 5amino salicylic acid acts on colitis mucosa, inhibits the formation of prostaglandins, leukotrienes and other inflammatory factors, and reduces membrane permeability, and plays a role in the treatment of ulcerative colitis. This product weakens the absorption of nitrogen, sodium and water in the ileum and colonic mucosa, which is transformed into secretion in human body. Patients with ulcerative colitis take 1g daily, and the whole intestinal transit time is shortened by 40%. ?If the healthy subjects are given oral administration of 2g once, It has no effect on the complex frequency of migration of the small intestine. But it can cause diarrhea in 30% of the users and increase the diarrhea of the patients with intestinal inflammation. ?The bioavailability of the whole body is extremely low. The absorption rate of the oral dose is less than 5%. After absorption, about 10% doses will be conjugated to orsalazine sulfate, t1/2 about 1H and conjugated half life is about 7 days. Figure 1 The structural formula of oralalazine sodium

Definition

ChEBI: An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of action unknown, but appears to be topical

Uses

Dimer of Mesalamine. It is an anti-inflammatorydrug used in the treatment of inflammatory bowel disease and ulcerative colitis

6054-98-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (O0146000)  Olsalazine sodium  European Pharmacopoeia (EP) Reference Standard 6054-98-4 O0146000 1,880.19CNY Detail
Sigma-Aldrich (O0146010)  Olsalazine sodium for performance test  European Pharmacopoeia (EP) Reference Standard 6054-98-4 O0146010 1,880.19CNY Detail

6054-98-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name olsalazine sodium

1.2 Other means of identification

Product number -
Other names Olsalazine disodium

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6054-98-4 SDS

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