60544-12-9Relevant academic research and scientific papers
Transition metal complex, chiral alpha-amino tertiary borate and preparing methods thereof
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Paragraph 0076; 0077; 0080; 0081-0084; 0111; 0112, (2017/07/21)
The invention discloses a transition metal complex, chiral alpha-amino tertiary borate and preparing methods thereof. The chiral alpha-amino tertiary borate preparing method comprises the step of mixing a compound II, a metal ligand complex and bis(pinaco
Synthesis of chiral α-amino tertiary boronic esters by enantioselective hydroboration of α-arylenamides
Hu, Naifu,Zhao, Guoqing,Zhang, Yuanyuan,Liu, Xiangqian,Li, Guangyu,Tang, Wenjun
, p. 6746 - 6749 (2015/06/16)
The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).
N, N′-dioxide-Cu(OTf)2 complex catalyzed highly enantioselective amination reaction of N-acetyl enamide
Chang, Lu,Kuang, Yulong,Qin, Bo,Zhou, Xin,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 2214 - 2217 (2010/08/06)
The N,N′-dioxide-Cu(OTf)2 complexes were applied in the asymmetric amination reaction of N-acetyl enamides with dialkyl azodicarboxylate, giving the corresponding products in good yields with high enantioselectivities (up to 91% ee). Precursors of vicinal diamine were readily obtained with excellent diastereoselectivities (>95:5) by NaBH4 reduction.
Rhodium/MonoPhos-Catalysed Asymmetric Hydrogenation of Enamides
Van Den Berg, Michel,Haak, Robert M.,Minnaard, Adriaan J.,De Vries, Andre H. M.,De Vries, Johannes G.,Feringa, Ben L.
, p. 1003 - 1007 (2007/10/03)
The monodentate phosphoramidite MonoPhos has been used in the rhodium-catalysed asymmetric hydrogenation of N-acetyl-α-arylenamides. This ligand is readily available via a one-step procedure and is air stable. Its Rh(I) complex, which is an effective catalyst precursor for the hydrogenation of dehydroamino acids, also gives high enantioselectivities for this class of substrates. Because of the facile synthesis and stability of MonoPhos, its complex provides a general solution in preparing chiral amine derivatives through asymmetric hydrogenation.
