60546-75-0Relevant academic research and scientific papers
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine1
Angeli, Andrea,Bartolucci, Gianluca,Biliotti, Caterina,Braconi, Laura,Dei, Silvia,Maach, Soumia,Romanelli, Maria Novella,Supuran, Claudiu T.,Teodori, Elisabetta,Chiaramonte, Niccolò
, p. 1003 - 1010 (2020/05/16)
The Carbonic Anhydrase (CA, EC 4.2.1.1) activating properties of histamine have been known for a long time. This compound has been extensively modified but only in few instances the imidazole ring has been replaced with other heterocycles. It was envisage
C-N Bond forming reactions in the synthesis of substituted 2-aminoimidazole derivatives
Gomez-SanJuan, Asier,Botija, Jose Manuel,Mendez, Almudena,Sotomayor, Nuria,Letea, Esther
, p. 44 - 56 (2014/03/21)
Carbon-nitrogen bond forming reactions oriented to the synthesis of 2-amino-imidazolidines and imidazoles have been investigated. The C-2 amination of imidazolidinones, via the corresponding 2-chlorodihydroimidazoles, led to 2-benzylaminodihydroimidazole or bis(dihydroimidazole)amino derivatives by choosing the adequate experimental conditions. On the other hand, the use of N-acyl-2-methylsulfanyldihydroimidazoles allowed carrying out the reactions with aromatic amines, such as p-anisidine. Finally, palladium catalyzed Buchwald- Hartwig amination was the method of choice for C-N coupling between 2-haloimidazoles and aromatic amines in the synthesis of the corresponding imidazoles.
A novel method for the efficient synthesis of 2-arylamino-2-imidazolines
Mundla,Wilson,Klopfenstein,Seibel,Nikolaides
, p. 6563 - 6566 (2007/10/03)
A novel method for the efficient synthesis of 2-arylamino-2-imidazolines is described. (C) 2000 Elsevier Science Ltd.
