60547-94-6

Upstream product

• 60547-92-4 4-(benzyloxy)-5-methoxy-2-nitrobenzoic acid 
• 2426-84-8 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 

Downstream Products

• 196603-96-0 4-(4-bromo-2-fluorophenylamino)-7-hydroxy-6-methoxyquinazoline 
• 768350-54-5 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine hydrochloride 
• 179688-01-8 7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one 
• 193001-44-4 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride 
• 338992-20-4 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1363151-84-1 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-(piperidinyl-4-methoxy)quinazolin-4-amine hydrochloride 
• 1363151-86-3 (S)-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)-1-(piperidinyl-2-pyrrolidinyl)methanone hydrochloride 
• 1363153-84-7 C₃₇H₄₈BrFN₆O₆ 
• 1363153-79-0 (S)-N-((S)-1-((S)-2-(4-((4-bromo-2-fluorophenylamino)-6-methoxyquinazolinyl-7-oxy)methyl)piperidine)-1-carbonyl)-1-((pyrrolidinyl)-3,3-dimethyloxobutan-2-yl)-2-(methylamino)propanamide hydrochloride 
• 1363150-67-7 C₄₁H₅₅BrFN₇O₇ 
• 1363153-82-5 C₃₁H₃₇BrFN₅O₅ 

Relevant academic research and scientific papers

QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS

Provided is a pharmaceutical composition comprising, as an active ingredient, a quinoline or quinazoline derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof, which is effective in the prevention and treatment of a cancer, inflammation, autoimmune diseases or neurodegenerative disorders which are induced by the overexpression of inhibitor of apoptosis proteins (IAPs).

Synthesis and identification of the major metabolites of prazosin formed in dog and rat

The 6 O demethyl and 7 O demethyl analogues of the new antihypertensive drug prazosin [2 [4 (2 furoyl) piperazin 1 yl] 4 amino 6,7 dimethoxyquinazoline hydrochloride] have been unequivocally synthesized via separate ten step reaction sequences starting from isovanillin and vanillin, respectively. The 6 O demethyl derivative was found to be identical with the major prazosin metabolite formed in dog and rat, while the 7 O demethyl derivative was identical with another, less prevalent but significant metabolite. Two minor metabolites of prazosin, 2 (1 piperazinyl) 4 amino 6,7 dimethoxyquinazoline and 2,4 diamino 6,7 dimethoxyquinazoline, are also described. All four metabolites are less potent blood pressure lowering agents in dogs than prazosin but may contribute to its antihypertensive effect, since they account for a major portion of the administered dose.