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60548-62-1

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60548-62-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 60548-62-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,4 and 8 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 60548-62:
(7*6)+(6*0)+(5*5)+(4*4)+(3*8)+(2*6)+(1*2)=121
121 % 10 = 1
So 60548-62-1 is a valid CAS Registry Number.

60548-62-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-sulfamoyloxybutyl sulfamate

1.2 Other means of identification

Product number -
Other names Sulfamic acid 4-sulfamoyloxy-butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60548-62-1 SDS

60548-62-1Upstream product

60548-62-1Downstream Products

60548-62-1Relevant articles and documents

Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates

Winum, Jean-Yves,Pastorekova, Silvia,Jakubickova, Lydia,Montero, Jean-Louis,Scozzafava, Andrea,Pastorek, Jaromir,Vullo, Daniela,Innocenti, Alessio,Supuran, Claudiu T.

, p. 579 - 584 (2007/10/03)

A series of bis-sulfamates incorporating aliphatic, aromatic, or betulinyl moieties in their molecules was obtained by reaction of the corresponding diols/diphenols with sulfamoyl chloride. The library of bis-sulfamates thus obtained was tested for the inhibition of three physiologically relevant human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, the cytosolic hCA I and II, and the transmembrane, tumor-associated hCA IX. The new compounds reported here inhibited hCA I with KI s in the range of 79 nM-16.45 μM, hCA II with KI s in the range of 6-643 nM, and hCA IX with KI s in the range of 4-5400 nM. Several low nanomolar hCA IX inhibitors were detected, such as 1,8-octylene-bis-sulfamate or 1,10-decylene-bis-sulfamate (KI s in the range of 4-7 nM), which showed good selectivity ratios (in the range of 3.50-3.85) for hCA IX over hCA II inhibition. The most selective hCA IX inhibitor was phenyl-1,4-dimethylene-bis-sulfamate (K I of 61.6 nM), which was a 10.43 times better hCA IX than hCA II inhibitor. These derivatives are interesting candidates for the development of novel antitumor therapies targeting hypoxic tumors, since hCA IX is highly overexpressed in such tissues, and its presence is correlated with bad prognosis and unfavorable clinical outcome.

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