60548-64-3Relevant articles and documents
Synthesis and Evaluation of the Male Antifertility Properties of a Series of N-Unsubstituted Sulfamates
Hirsch, Allen F.,Kasulanis, Charles,Kraft, Larry,Mallory, Robert A.,Powell, Gregory,Wong, Benny
, p. 901 - 903 (2007/10/02)
A series of six aliphatic and one carbocyclic N-unsubstituted sulfamates have been synthesized and evaluated as potential male antifertility agents.Three of the aliphatic sulfamates 1,2-ethanediyl sulfamate (1), 1,3-propanediyl sulfamate (2), and 1,4-butanediyl sulfamate (3), when administered orally to male rats caused a decrease in the number of pregnant females and/or implantation coupled with increased embryonic and fetal resorption.The compounds were prepared by treating the appropriate glycol salt with sulfamoyl chloride or by the cleavage of a tert-butylsulfamate with trifluoroacetic acid.