60557-11-1

Basic information

• Product Name: N,2-diphenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine
• Synonyms: N,2-diphenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine
• CAS NO: 60557-11-1
• Molecular Weight: 357.479
• Mol File: 60557-11-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,2-diphenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N,2-diphenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine(60557-11-1)
• EPA Substance Registry System: N,2-diphenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine(60557-11-1)

Safety Data

• Hazardous Substances Data: 60557-11-1(Hazardous Substances Data)

Upstream product

• 19819-18-2 2-phenyl-5,6-tetramethylenethieno<2,3-d>pyrimidin-4(3H)-one 
• 19819-18-2 4-hydroxy-2-phenyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyrimidine 
• 62-53-3 aniline 
• 19819-17-1 2-benzamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 4815-28-5 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide 
• 108-94-1 cyclohexanone 

Relevant articles and documents

Anti-tubercular activities of 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine analogues endowed with high activity toward non-replicative Mycobacterium tuberculosis

Thirty three derivatives of 2-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine analogues were synthesized by molecular modification of a reported antimycobacterial molecule (GSK163574A). Compounds were evaluated in vitro against actively replicative and nutrient starved non-replicative Mycobacterium tuberculosis (MTB), enzymatic screening and cytotoxicity against RAW 264.7 cell line. Among the compounds, 2-ethyl-N-phenethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine (5c) was found to be the most active compound against non-replicative MTB with 2.7 log reduction of bacteria at 10?μg/mL and was more potent than isoniazid (1.2 log reduction) and rifampicin (2.0 log reduction) at same dose level. Compound 5c also showed activity against MTB alanine dehydrogenase enzyme with IC50of 1.82?±?0.42?μM and showed 25% cytotoxicity against RAW 264.7 cell line at 50?μg/mL.