60558-61-4Relevant academic research and scientific papers
AMINATION REDUCTRICE D'ALDEHYDES PHOSPHONIQUES. Un Reexamen
Collignon, N.,Fabre, G.,Varlet, J. M.,Savignac, Ph.
, p. 81 - 86 (2007/10/02)
The reactivity of diethyl-2-oxo ethyl- and 3-oxo propylphosphonates with ammonia, methyl and dimethylamine at pH 7 in the presence of sodium cyanohydridoborate via reductive amination of the carbonyl group has been reexamined.Reactions of diethyl-2-oxoethyl- and 3-oxopropylphosphonates with ammonia give imino-bis-(alkylphosphonates); methyl and dimethylamine give monocondensation products thus permitting the synthesis of N-substituted aminoalkylphosphonates.
