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DCEBIO, also known as 1-Ethyl-2-benzimidazolinone, is a small molecule that acts as a Ca2+-sensitive K+ channel (SKCa) agonist. It possesses the ability to stimulate nitric oxide (NO) synthesis and induce vasodilation in resistance arteries. This unique combination of properties makes DCEBIO a promising candidate for various applications in the field of medicine and pharmacology.

60563-36-2

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60563-36-2 Usage

Uses

Used in Pharmaceutical Applications:
DCEBIO is used as a SKCa channel agonist for its ability to modulate the activity of these channels, which play a crucial role in various physiological processes. By targeting SKCa channels, DCEBIO has potential applications in treating conditions related to ion channel dysfunction.
Used in Cardiovascular Applications:
DCEBIO is used as a vasodilator for its ability to stimulate nitric oxide (NO) synthesis, leading to the relaxation of vascular smooth muscle cells and subsequent vasodilation. This property makes DCEBIO a potential therapeutic agent for treating conditions associated with vasoconstriction, such as hypertension and peripheral artery disease.
Used in Research Applications:
DCEBIO is used as a research tool for studying the role of SKCa channels and nitric oxide in various physiological and pathological processes. Its ability to modulate these pathways allows researchers to gain insights into the underlying mechanisms of ion channel dysfunction and the role of nitric oxide in vascular health.

Biological Activity

Stimulates Cl - secretion via activation of hIK1 K + channels and the activation of an apical Cl - conductance. More potent than its analog 1-EBIO (1-Ethyl-2-benzimidazolinone ).

Check Digit Verification of cas no

The CAS Registry Mumber 60563-36-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,6 and 3 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60563-36:
(7*6)+(6*0)+(5*5)+(4*6)+(3*3)+(2*3)+(1*6)=112
112 % 10 = 2
So 60563-36-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14)

60563-36-2 Well-known Company Product Price

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  • Sigma

  • (D9190)  DCEBIO  ≥98% (HPLC), solid

  • 60563-36-2

  • D9190-5MG

  • 1,655.55CNY

  • Detail
  • Sigma

  • (D9190)  DCEBIO  ≥98% (HPLC), solid

  • 60563-36-2

  • D9190-25MG

  • 6,575.40CNY

  • Detail

60563-36-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one

1.2 Other means of identification

Product number -
Other names 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:60563-36-2 SDS

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