60595-15-5

Upstream product

• 7205-91-6 phenylthiomethyl chloride 
• 41804-89-1 potassium triflinate 

Downstream Products

• 836-97-5 [(phenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane 
• 140397-03-1 C₂₆H₂₅F₃O₆S₂ 
• 140396-99-2 C₂₅H₂₄O₄S 
• 141354-69-0 C₂₅H₂₄O₄S 
• 140397-02-0 (1S,2S)-4-Benzenesulfonyl-4-trifluoromethanesulfonyl-cyclopentane-1,2-diol 
• 140396-94-7 (5-Iodo-1-trifluoromethanesulfonyl-pentane-1-sulfonyl)-benzene 
• 140396-95-8 (1-Trifluoromethanesulfonyl-cyclopentanesulfonyl)-benzene 
• 140396-98-1 (1S,2S,4S)-4-Benzenesulfonyl-bicyclo[2.1.0]pentan-2-ol 
• 140396-96-9 2-cyclopenten-1-yl phenyl sulfone 

Relevant academic research and scientific papers

Synthesis and endectocidal activity of novel 1-(Arylsulfonyl)-1- [(trifluoromethyl)sulfonyl]methane derivatives

We have recently synthesized a series of novel disulfonylmethane compounds that have shown anthelmintic and insecticidal (endectocidal) activity. Several analogues have shown activity against the internal nematode Haemonchus contortus. In sheep studies, these analogues have shown 100% control of this internal parasite at a 10 mg/kg rate. In vitro activity against the biting flies, Stomoxys calcitrans and Haematobia irritans, has been observed at rates as low as 25 and 2.3 ppm, respectively. Only marginal activity against the liver fluke Fasciola hepatica and Trichostrongylus colubriformis was seen. Respiratory control index values on rat liver mitochondria for this series suggested uncoupling of oxidative phosphorylation as a mechanism of action. Compound 1 is considered to be a promising agent for treatment of parasitized sheep.

Use of disulfonyl methanes for the control of parasites

The present invention is directed to the use of disulfonyl methane compounds for the control of parasites in vertebrate animals.

BIS-ALKYLATION OF DIMETALLATED PHENYLSULFONYLMETHYL TRIFLONE. A n+1 ANNULATION STRATEGY FOR SYNTHESIS OF CYCLIC VINYL SULFONES

Bis-metallation of phenylsulfonylmethyl triflone 4b produces a geminal dianion which can be dialkylated to afford α-phenylsulfonyl triflones.Treatment of these compounds with DBU affords vinyl sulfones which can be isomerized to allyl sulfones.