606-13-3

Upstream product

• 64-17-5 ethanol 
• 548-93-6 3-hydroxyanthranilic acid 

Downstream Products

• 123154-04-1 N-acetyl-3-hydroxy ethyl anthranilate 
• 123154-05-2 N-acetyl-3-acetoxy ethyl anthranilate 
• 729591-75-7 ethyl 3-hydroxy-2-(4-trifluoromethylbenzoylamino)benzoate 
• 171861-87-3 2-methyl-4-benzoxazolecarboxylic acid 
• 365462-85-7 ethyl 2-amino-5-chloro-3-hydroxybenzoate 
• 365462-86-8 2-amino-5-chloro-3-hydroxybenzoic Acid 
• 1108172-90-2 2-methyl-benzooxazole-4-carboxylic acid ethyl ester 
• 123154-11-0 2-(Acetyl-methyl-amino)-3-(2-isopropyl-[1,3]dioxolan-2-ylmethoxy)-benzoic acid ethyl ester 
• 123154-10-9 2-Acetylamino-3-(2-isopropyl-[1,3]dioxolan-2-ylmethoxy)-benzoic acid ethyl ester 
• 123154-09-6 N-acetyl-3(3-methyl-2-oxobutoxy)ethyl anthranilate 
• 123154-12-1 4-Hydroxy-8-(2-isopropyl-[1,3]dioxolan-2-ylmethoxy)-1-methyl-1H-quinolin-2-one 
• 123154-07-4 N-acetyl-N-methyl-3(3-methyl-2-butenyl)oxy ethyl anthranilate 
• 123154-06-3 N-acetyl-3-(3-methyl-2-butenyl)oxy-ethyl anthranilate 

Relevant academic research and scientific papers

Natural Product Chemistry. Part 116. Synthesis of Daurine and Folidine: Two 2(1H)-Quinolinone Alkaloids from Haplophyllum Species

Structures of the recently isolated 2(1H)-quinolinone alkaloids, daurine and folidine have been confirmed by total synthesis. - Keywords: Alkaloids; Daurine; Folidine; Haplophyllum; 2(1H)-Quinolinones; Rutaceae; Total synthesis

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

PH Induced dual "oFF-ON-OFF" switch: Influence of a suitably placed carboxylic acid

The design and synthesis of molecular probes competent for pH signaling within or beyond a certain range is a complicated matter. Herein a new mechanism for ''OFF-ON-OFF'' absorbance and fluorescence intensities vs. pH behaviour is described. The probe design is based on the connection of carboxylic acid derivatized benzoxazole and 7-hydroxycoumarin/iminocoumarin parts. The protonation/deprotonation of the carboxylic acid (-COOH), N atom of benzoxazole ring and hydroxy part of the coumarin ring have been used for this mechanistic study. We have designed the molecule in such a fashion that deprotonation of the hydroxy part takes place at a lower pKa compared to deprotonation of the -COOH. The dual ''OFF-ON-OFF'' properties of our probes depend on the C-C bond between the two different heterocyclic parts. Quantum mechanical calculations showed that the particular 'C-C' bond has an additional π-character. The twisting around this bond in different forms is responsible for such an ''OFF-ON-OFF'' property. This mechanism is new in fluorescence alteration processes. The delocalization of charge from one heterocyclic part to the other heterocyclic part in the mono- and dianionic forms controls the ''OFF-ON-OFF'' properties. The role of the carboxylic acid group was examined using an acetyl substituted derivative. One of our probes was successfully applied in live cell imaging studies in media at different pH.

FUSED HETEROCYCLIC DERIVATIVES AS PPAR MODULATORS

The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S. S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.