60601-59-4Relevant academic research and scientific papers
Catalytic enantioselective synthesis of a-aryl a-hydrazino esters and amides
Alberca, Saúl,Fernández, Rosario,Iglesias-Sigüenza, Javier,Lassaletta, José M.,Monge, David,Velázquez, Marta
, p. 5823 - 5826 (2020)
Catalysts generated by combinations of Pd(TFA)2and pyridine-hydrazone ligands have allowed the asymmetric 1,2-addition of aryl boronic acids toN-carbamoyl (Cbz and Fmoc) protected glyoxylate-derived hydrazones, yielding a-aryl a-hydrazino esters/amides in high enantioselectivities. Subsequent removal of the carbamoyl moiety affords key building blocks en route to hydrazinopeptides,N-aminopeptides and peptidomimetics thereof.
