60607-35-4 Usage
Uses
Topterone functions as steroidal antiandrogen drug. Also, the are used in acne and androgenic alopecia treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 60607-35-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,6,0 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60607-35:
(7*6)+(6*0)+(5*6)+(4*0)+(3*7)+(2*3)+(1*5)=104
104 % 10 = 4
So 60607-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H34O2/c1-4-10-22(24)13-9-19-17-6-5-15-14-16(23)7-11-20(15,2)18(17)8-12-21(19,22)3/h14,17-19,24H,4-13H2,1-3H3/t17?,18-,19-,20?,21?,22-/m0/s1
60607-35-4Relevant articles and documents
Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III)Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-one, An Androgen Receptor Antagonist
Li, Xun,Singh, Shankar M.,Labrie, Fernand
, p. 1157 - 1160 (2007/10/02)
The addition of alkyl Grignard reagents to sterically hindered 17-ketosteroids was significantly enhanced by anhydrous cerium(III) chloride with notable suppression of abnormal reactions, while the addition products were obtained in good to excellent yields and high stereoselectivity.