606099-68-7Relevant academic research and scientific papers
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases
Ji, Zhiqin,Ahmed, Asma A.,Albert, Daniel H.,Bouska, Jennifer J.,Bousquet, Peter F.,Cunha, George A.,Glaser, Keith B.,Guo, Jun,Li, Junling,Marcotte, Patrick A.,Moskey, Maria D.,Pease, Lori J.,Stewart, Kent D.,Yates, Melinda,Davidsen, Steven K.,Michaelides, Michael R.
, p. 4326 - 4330 (2006)
A series of isothiazolopyrimidines and isoxazolopyrimidines were synthesized and identified as potent KDR inhibitors. SAR studies led to isothiazolopyrimidine urea analogs that potently inhibit VEGFR tyrosine kinases (KDR enzymatic and cellular IC50
Kinase inhibitors
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Page 36, (2010/02/03)
The present application is directed to pyrazolopyrirnidine and furopyrimidine analogs of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
Kinase inhibitors
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, (2008/06/13)
The present application is directed to pyrazolopyrimidine and furopyrimnidine analogs of the formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
