606115-77-9 Usage
Chemical structure
A complex organic compound with a thiadiazole ring, an amide group, and various substituents.
Molecular weight
360.43 g/mol
Appearance
A solid, white to off-white crystalline powder.
Solubility
Soluble in organic solvents such as dimethyl sulfoxide (DMSO) and methanol, with limited solubility in water.
Mechanism of action
A histone-lysine N-methyltransferase EZH2 inhibitor, which means it inhibits the activity of the EZH2 enzyme involved in protein modification.
Therapeutic applications
Potential use in the treatment of various types of cancer, including lymphoma and solid tumors.
Targeted therapy
Being investigated as a targeted therapy for specific cancer conditions.
Preclinical studies
Shown promise in preclinical studies for cancer treatment.
Clinical trials
Ongoing clinical trials to evaluate the safety and efficacy of Tazametostat in cancer treatment.
Synonyms
Tazemetostat, EPZ-6438, and KF-07132.
Chemical classification
A small molecule inhibitor.
Development
Originally developed by Epizyme, Inc., and later acquired by Roche.
Regulatory status
Approved by the FDA for the treatment of certain types of epithelioid sarcoma in January 2020.
Check Digit Verification of cas no
The CAS Registry Mumber 606115-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,6,1,1 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 606115-77:
(8*6)+(7*0)+(6*6)+(5*1)+(4*1)+(3*5)+(2*7)+(1*7)=129
129 % 10 = 9
So 606115-77-9 is a valid CAS Registry Number.
