Cas 606143-91-3,1H-Benzimidazole-5-carboxylic acid, 6-[(4-bromo-2-methylphenyl)amino]-7-fluoro-, methyl ester

606143-91-3

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Basic information

Product Name: 1H-Benzimidazole-5-carboxylic acid, 6-[(4-bromo-2-methylphenyl)amino]-7-fluoro-, methyl ester
Synonyms:
CAS NO:606143-91-3
Molecular Formula: C16H13BrFN3O2
Molecular Weight: 378.201
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1H-Benzimidazole-5-carboxylic acid, 6-[(4-bromo-2-methylphenyl)amino]-7-fluoro-, methyl ester(CAS DataBase Reference)
NIST Chemistry Reference: 1H-Benzimidazole-5-carboxylic acid, 6-[(4-bromo-2-methylphenyl)amino]-7-fluoro-, methyl ester(606143-91-3)
EPA Substance Registry System: 1H-Benzimidazole-5-carboxylic acid, 6-[(4-bromo-2-methylphenyl)amino]-7-fluoro-, methyl ester(606143-91-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 606143-91-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 606143-91-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,6,1,4 and 3 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 606143-91:
(8*6)+(7*0)+(6*6)+(5*1)+(4*4)+(3*3)+(2*9)+(1*1)=133
133 % 10 = 3
So 606143-91-3 is a valid CAS Registry Number.

606143-91-3Upstream product

284030-61-1 methyl 7-fluoro-6-(2-methyl-phenylamino)-1H-benzoimidazole-5-carboxylate

606143-91-3Downstream Products

606143-91-3Relevant academic research and scientific papers

N3 alkylated benzimidazole derivatives as MEK inhibitors

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Page 9; 16; 17, (2008/06/13)

Disclosed are compounds of the formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.

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