606149-63-7Relevant academic research and scientific papers
Tandem three-component reaction of aldehyde, alkyl acrylate, and amide using ethyl diphenylphosphine as organocatalyst
Syu, Siang-En,Wang, De-Wei,Chen, Pei-Yi,Hung, Yi-Ting,Jhang, Yi-Wun,Kao, Tzu-Ting,Lee, Yu-Ting,Lin, Wenwei
, p. 5943 - 5946 (2010)
It is the first time that a chemoselective EtPPh2-catalyzed three-component reaction of aromatic aldehyde, alkyl acrylate, and phthalimide or methyl toluenesulfonamide has been achieved. A variety of highly functional adducts can be generated efficiently in one step within 1-72 h in 38-93% yields. The reaction mechanism is proposed to undergo Morita-Baylis-Hillman reactions of aryl-substituted aldehydes and alkyl acrylates followed by Michael additions of amides. Our studies indicated that, in combination of EtPPh2, alkyl acrylate also catalyzed this process.
