60632-94-2Relevant academic research and scientific papers
Modular approach to reductive Csp2-H and Csp3-H silylation of carboxylic acid derivatives through single-pot, sequential transition metal catalysis
Hua, Yuanda,Jung, Seongjeong,Roh, James,Jeon, Junha
, p. 4661 - 4671 (2015/05/13)
We report a modular approach to catalytic reductive Csp2-H and Csp3-H silylation of carboxylic acid derivatives encompassing esters, ketones, and aldehydes. Choice of either an Ir(I)/Rh(I) or Rh(I)/Rh(I) sequence leads to either exhaustive reductive ester or reductive ketone/aldehyde silylation, respectively. Notably, a catalyst-controlled direct formation of doubly reduced silyl ethers is presented, specifically via Ir-catalyzed exhaustive hydrosilylation. The resulting silyl ethers undergo Csp2-H and benzylic Csp3-H silylation in a single vessel.
