60633-24-1

Basic information

• Product Name: Thiazole, 2,5-dihydro-2,4,5-triMethyl-
• Synonyms: Thiazole, 2,5-dihydro-2,4,5-triMethyl-;2,4,5-trimethyl-2,5-dihydro-1,3-thiazole
• CAS NO: 60633-24-1
• Molecular Formula: C₆H₁₁NS
• Molecular Weight: 129.22324
• Mol File: 60633-24-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 178.766 °C at 760 mmHg
• Flash Point: 61.916 °C
• Appearance: /
• Density: 1.106 g/cm³
• Vapor Pressure: 1.32mmHg at 25°C
• Refractive Index: 1.563
• PKA: 6.97±0.60(Predicted)
• CAS DataBase Reference: Thiazole, 2,5-dihydro-2,4,5-triMethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazole, 2,5-dihydro-2,4,5-triMethyl-(60633-24-1)
• EPA Substance Registry System: Thiazole, 2,5-dihydro-2,4,5-triMethyl-(60633-24-1)

Safety Data

• Hazardous Substances Data: 60633-24-1(Hazardous Substances Data)

Usage

General Description

Thiazole, 2,5-dihydro-2,4,5-triMethyl- is a chemical compound with the molecular formula C6H9NS. It is a highly flammable liquid with a faint odor and is primarily used in the production of agricultural chemicals, pharmaceuticals, and dyes. Thiazole, 2,5-dihydro-2,4,5-triMethyl- is also used as a solvent and in the manufacturing of rubber and plastics. Thiazole, 2,5-dihydro-2,4,5-triMethyl- may pose health hazards if inhaled or ingested and should be handled with caution in a controlled laboratory setting.

InChI:InChI=1/C6H11NS/c1-4-5(2)8-6(3)7-4/h5-6H,1-3H3

Synthetic route

3-mercapto-2-butanone (40789-98-8) + acetaldehyde (75-07-0) → (E,Z)-2,4,5-trimethyl-Δ3-thiazoline (60633-24-1)

Conditions	Yield
With ammonia at 0℃; for 2h;	44%
With ammonia

Upstream product

• 40789-98-8 3-mercapto-2-butanone 
• 75-07-0 acetaldehyde 

Relevant articles and documents

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Innate behaviors are genetically encoded, but their underlying molecular mechanisms remain largely unknown. Predator odor 2,4,5-trimethyl-3-thiazoline (TMT) and its potent analog 2-methyl-2-thiazoline (2MT) are believed to activate specific odorant receptors to elicit innate fear/defensive behaviors in naive mice. Here, we conduct a large-scale recessive genetics screen of ethylnitrosourea (ENU)-mutagenized mice. We find that loss of Trpa1, a pungency/irritancy receptor, diminishes TMT/2MT and snake skin-evoked innate fear/defensive responses. Accordingly, Trpa1 -/- mice fail to effectively activate known fear/stress brain centers upon 2MT exposure, despite their apparent ability to smell and learn to fear 2MT. Moreover, Trpa1 acts as a chemosensor for 2MT/TMT and Trpa1-expressing trigeminal ganglion neurons contribute critically to 2MT-evoked freezing. Our results indicate that Trpa1-mediated nociception plays a crucial role in predator odor-evoked innate fear/defensive behaviors. The work establishes the first forward genetics screen to uncover the molecular mechanism of innate fear, a basic emotion and evolutionarily conserved survival mechanism.