60633-24-1

Usage

Uses

Used in Agricultural Chemicals:
Thiazole, 2,5-dihydro-2,4,5-triMethylis used as a key component in the production of agricultural chemicals for its ability to enhance the effectiveness of various agrochemicals, contributing to improved crop protection and yield.
Used in Pharmaceuticals:
In the pharmaceutical industry, Thiazole, 2,5-dihydro-2,4,5-triMethylis utilized as an intermediate in the synthesis of various drugs, leveraging its chemical properties to facilitate the creation of new medicinal compounds.
Used in Dyes:
Thiazole, 2,5-dihydro-2,4,5-triMethylis employed in the dye industry as a constituent in the formulation of different types of dyes, capitalizing on its chemical structure to produce a spectrum of colors.
Used as a Solvent:
Thiazole, 2,5-dihydro-2,4,5-triMethylalso serves as a solvent in various chemical processes, providing a medium for reactions to occur and enhancing the efficiency of these processes.
Used in Rubber and Plastics Manufacturing:
Thiazole, 2,5-dihydro-2,4,5-triMethylis used in the manufacturing of rubber and plastics, where it contributes to the properties of the final products, such as flexibility, durability, and color.

InChI:InChI=1/C6H11NS/c1-4-5(2)8-6(3)7-4/h5-6H,1-3H3

Synthetic route

3-mercapto-2-butanone (40789-98-8) + acetaldehyde (75-07-0) → (E,Z)-2,4,5-trimethyl-Δ3-thiazoline (60633-24-1)

Conditions	Yield
With ammonia at 0℃; for 2h;	44%
With ammonia

Upstream product

• 40789-98-8 3-mercapto-2-butanone 
• 75-07-0 acetaldehyde 

Relevant academic research and scientific papers

Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Innate behaviors are genetically encoded, but their underlying molecular mechanisms remain largely unknown. Predator odor 2,4,5-trimethyl-3-thiazoline (TMT) and its potent analog 2-methyl-2-thiazoline (2MT) are believed to activate specific odorant receptors to elicit innate fear/defensive behaviors in naive mice. Here, we conduct a large-scale recessive genetics screen of ethylnitrosourea (ENU)-mutagenized mice. We find that loss of Trpa1, a pungency/irritancy receptor, diminishes TMT/2MT and snake skin-evoked innate fear/defensive responses. Accordingly, Trpa1 -/- mice fail to effectively activate known fear/stress brain centers upon 2MT exposure, despite their apparent ability to smell and learn to fear 2MT. Moreover, Trpa1 acts as a chemosensor for 2MT/TMT and Trpa1-expressing trigeminal ganglion neurons contribute critically to 2MT-evoked freezing. Our results indicate that Trpa1-mediated nociception plays a crucial role in predator odor-evoked innate fear/defensive behaviors. The work establishes the first forward genetics screen to uncover the molecular mechanism of innate fear, a basic emotion and evolutionarily conserved survival mechanism.