6065-32-3

Usage

Uses

Used in Chemical Synthesis:
Ethyl 4-bromocrotonate is used as a synthetic intermediate for the production of various chemical compounds. Its role in this application is to facilitate the synthesis of target molecules, making it a valuable component in the chemical industry.
Used in Pharmaceutical Synthesis:
Ethyl 4-bromocrotonate is used as a chemical intermediate in the synthesis of pharmaceuticals. It plays a crucial role in the development of new drugs, contributing to the advancement of medicine and healthcare.
Used in Research and Development:
Ethyl 4-bromocrotonate is used as a research compound for the study of chemical reactions and processes. It aids in understanding the behavior of organic halogen compounds and their potential applications in various fields.
Safety Precautions:
It is important to handle ethyl 4-bromocrotonate with care due to its potential to cause skin irritation, serious eye irritation, and harm if inhaled or swallowed. Appropriate safety measures should be taken when working with this chemical to minimize risks and ensure the safety of those involved in its use.

InChI:InChI=1/C6H9BrO2/c1-2-9-6(8)4-3-5-7/h3-4H,2,5H2,1H3/b4-3+

Upstream product

• 10544-63-5 ethyl crotonate 
• 623-70-1 ethyl (E)-crotonate 

Downstream Products

• 22008-57-7 5,9,13-Trimethyl-tetradecansaeure 
• 92904-43-3 Cyclohexanon-(1)-<γ-crotonsaeure>-(2)-aethylester 
• 2352-48-9 4-(3',5',5'-Trimethyl-2'-cyclohexyliden)-buten-⁽²⁾-saeure-ethylester 
• 94801-97-5 2-<3-Ethoxycarbonyl-allyl>-2-hydroxy-1,3-dimethyl-cyclohexan-carbonsaeure-ethylester 
• 59425-01-3 Aethyl-4-jod-crotonat 
• 101101-38-6 4-(2-Oxo-1-ethoxycarbonyl-cyclohexyl)-crotonsaeureethylester 
• 98269-39-7 (E)-4-(3-Oxo-cyclohexyl)-but-2-enoic acid ethyl ester 
• 98269-36-4 2-(1-Hydroxy-cyclohex-2-enyl)-but-3-enoic acid ethyl ester 
• 98269-37-5 (E)-4-(1-Hydroxy-cyclohex-2-enyl)-but-2-enoic acid ethyl ester 
• 116425-58-2 ethyl 5-hydroxy-5-(3-methoxy-4-methylphenyl)-2-hexenoate 
• 130351-30-3 ethyl 5-<4-(tert-butoxycarbonyl)phenyl>-5-hydroxy-2-hexenoate 
• 133343-57-4 (E)-4-[(S)-2-Chloro-2,2-difluoro-1-((S)-toluene-4-sulfinylmethyl)-ethoxy]-but-2-enoic acid ethyl ester 
• 83611-34-1 4-(2-formylphenoxy)but-2-enoic acid ethyl ester 
• 98269-42-2 (2E,6E)-5-Hydroxy-5-methyl-7-phenyl-hepta-2,6-dienoic acid ethyl ester 

Relevant academic research and scientific papers

PROGRANULIN MODULATORS AND METHODS OF USING THE SAME

Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).

COMPOUNDS AND METHODS OF USE THEREOF

Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

Synthesis and herbicidal activity of diphenyl ether derivatives containing unsaturated carboxylates

A series of novel diphenyl ether derivatives containing unsaturated carboxylates were designed and synthesized. Their structures were identified by 1H nuclear magnetic resonance and elemental analyses. The bioassays indicated that the compounds 5b and 5c exhibited good herbicidal activities against velvetleaf at a concentration of 30-40 g/hm2. The relationship between structure and herbicidal activity was also discussed. Among unsaturated carboxylates group, butenoate is the most promising one. Amonst them, 4-ethoxy-4-oxobutenyl 5-(2-chloro-4-(trifluoromethyl)phenoxy)-2- nitrobenzoate 5b was identified as the most promising candidate due to its high protoporphyrinogen IX oxidase inhibition effect (pI50 = 6.64) and good herbicidal activity against broadleaf weeds with selectivity to soybean and low toxicity to mammals.

Bromination of organic allylic compounds by using N,N′-dibromo-N,N′-1,2-ethane diyl bis(2,5-dimethyl benzene sulphonyl)amine

N,N′-Dibromo-N,N′-1,2-ethane diyl bis(2,5-dimethyl benzene sulphonyl)amine is an efficient brominating agent for bromination of allylic positions of different organic compounds. This reagent in presence of benzoyl peroxide can brominates the allylic positions of organic compounds in ambient conditions in carbon tetrachloride.

Consecutive Ring Closure and Neophyl Rearrangement of Some Alkenylaryl Radicals

The endo cyclization products 4a, 18a, 18b, 25b, and 25c obtained from the reaction of tributylstannane with the bromoarenes 1a, 12a, 12b, 22b, and 22c, respectively, are formed, at least in part, by exo cyclization of the corresponding substituted aryl radicals followed by neophyl rearrangement of the initial products.Kinetic data show that the rearrangement is more rapid for the radicals 15a and 15b containing the naphtalene nucleus than it is for the benzenoid radicals 24b and 24c and is facilitated by the presence of the electron-attracting substituent in 3a.