60652-04-2

Basic information

• Product Name: Methyl 2-Methyl-3-oxoisoindoline-1-carboxylate
• Synonyms: Methyl 2-Methyl-3-oxoisoindoline-1-carboxylate
• CAS NO: 60652-04-2
• Molecular Formula: C11H11NO3
• Molecular Weight: 205.20994
• Mol File: 60652-04-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl 2-Methyl-3-oxoisoindoline-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-Methyl-3-oxoisoindoline-1-carboxylate(60652-04-2)
• EPA Substance Registry System: Methyl 2-Methyl-3-oxoisoindoline-1-carboxylate(60652-04-2)

Safety Data

• Hazardous Substances Data: 60652-04-2(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 29810-10-4 methyl α-(N,N-dimethylamino)phenylacetate 

Relevant articles and documents

Synthesis of conformationally restricted glutamate and glutamine derivatives from carbonylation of orthopalladated phenylglycine derivatives

A new method for the regioselective synthesis of 2-alkoxycarbonyl- and 2-(aminocarbonyl)phenylglycinate methyl esters has been developed. The reaction of the orthopalladated complex [Pd(μ-Cl)(C6H 4(CH(CO2Me)NMe2)-2)]2 (1) with nucleophiles HNu under a CO atmosphere results in the selective incorporation of the C(O)Nu moiety to the phenyl ring and formation of the carbonyl species ortho-C6H4(C(O)Nu)(CH(CO2Me)NMe2) (2a-j) (Nu = OR, NHR, NR2). Compounds 2a-j are conformationally restricted analogues of glutamic acid and glutamine and are interesting due to their biological and pharmacological properties. The reaction of [Pd(μ-Cl)(C6H4(CH(CO2Me)NHTf)-2)] 2 (3) with nucleophiles in a CO atmosphere results, however, in the formation of the cyclic isoindolinone or the open 2-carboxyphenylglycine methyl esters, with the reaction outcome being driven by the choice of the solvent.