60664-01-9

Upstream product

• 180028-93-7 6-amino-1-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 883022-42-2 C₁₁H₁₁N₃O₃ 
• 1566-42-3 p-anisidine urea 
• 104-94-9 4-methoxy-aniline 
• 2293-07-4 1-(4-methoxyphenyl)thiourea 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 1240506-41-5 4-amino-N-[1-(4-methoxyphenyl)-2,4,6-trioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]benzenesulfonamide 
• 900088-74-6 N-[1-(4-methoxyphenyl)-2,4,6-trioxo-5-trifluoromethyl-2,3,4,5,6,7-hexahydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]-4-acetamidobenzenesulfonamide 

Relevant academic research and scientific papers

Ionic liquid mediated one-pot synthesis of 6-aminouracils

A novel, one-pot synthesis of 6-aminouracils via in situ generated ureas and cyanoacetylureas in the presence of an ionic liquid catalyst, 1,1,3,3-tetramethylguanidine acetate, is described. The catalyst can be recycled for five consecutive runs without loss of activity. The mechanism for the ring closure of cyanoacetylurea to 6-aminouracil is also discussed.

Reactions of nitriles under acidic conditions : Part IX - Synthesis of 6-amino-1-aryluracils, 6-amino-1-aryl-2-thiouracils and 6-amino-1,3-diaryl-2-thiouracils under acidic conditions

6-Amino-1-aryluracils (11a-g), 6-amino-1-aryl-2-thiouracils (12a-g), and 6-amino-1,3-diaryl-2-thiouracils (6a,b) have been synthesised through the dry hydrogen chloride gas-catalysed condensation of ethyl cyanoacetate (7) with appropriate arylureas and thioureas. 1-Aryl (12a-g) and 1,3-diaryl-2-thiouracils (6c-g) have been converted to the corresponding 1-aryl (15a-g) and novel hitherto unre-ported, 1,3-diaryluracils (5a-e) through their oxidative desulphurisation.