60666-70-8

Basic information

• Product Name: 2-BROMO-5-CHLOROBENZYL ALCOHOL
• Synonyms: 2-BROMO-5-CHLOROBENZYL ALCOHOL;(2-Bromo-5-chlorophenyl)methanol;2-bromo-5-chloroBenzenemethanol
• CAS NO: 60666-70-8
• Molecular Formula: C₇H₆BrClO
• Molecular Weight: 221.47894
• Product Categories: Alcohols;Bromine Compounds;Chlorine Compounds
• Mol File: 60666-70-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 81-83°C
• Boiling Point: 290℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.685
• Vapor Pressure: 0.000972mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-5-CHLOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-CHLOROBENZYL ALCOHOL(60666-70-8)
• EPA Substance Registry System: 2-BROMO-5-CHLOROBENZYL ALCOHOL(60666-70-8)

Safety Data

• Hazardous Substances Data: 60666-70-8(Hazardous Substances Data)

Usage

Uses

2-Bromo-5-chlorobenzyl Alcohol is used to prepare fluorodihydrohydroxy benzoxaborole for potential treatment of onychomycosis. It is also an intermediate used to synthesize morpholylureas as potent and selective inhibitors of AKR1C3.

InChI:InChI=1/C7H6BrClO/c8-7-2-1-6(9)3-5(7)4-10/h1-3,10H,4H2

Upstream product

• 635-21-2 5-chloroanthranilic acid 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 21739-93-5 2-bromo-5-chlorobenzoic acid 

Downstream Products

• 845301-97-5 2-bromo-5-chloro-1-(methoxymethoxymethyl)benzene 
• 1273546-86-3 N-Boc-N-[2-(2-bromo-5-chloro-phenyl)ethyl]amine 
• 1379974-95-4 2-(2-bromo-5-chlorophenyl)ethan-1-amine 
• 127792-49-8 2-(2-bromo-5-chlorophenyl)acetonitrile 
• 1261761-66-3 ethyl 3-(2-bromo-5-chloro-phenyl)propanoate 
• 947614-94-0 2-(2-bromo-5-chloro-phenyl)ethanol 
• 265107-67-3 (2-bromo-5-chlorophenyl)acetaldehyde 
• 1308314-91-1 (+)-(1S,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-7-chloro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[benzo[c]oxepine-1,2'-pyran]-3'-ol 
• 1308314-90-0 (+)-(1S,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-6-chloro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydrospiro[isochroman-1,2'-pyran]-3'-ol 
• 1308314-66-0 (+)-(1R,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-6-chloro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydrospiro[isochroman-1,2'-pyran]-3'-ol 
• 1308314-89-7 (+)-(1S,3'R,4'S_.6'R)-6'-(2-(tert-butyldiphenylsilyloxy)ethyl)-5-chloro-4'-(triisopropylsilyloxy)-3',4',5',6'-tetrahydro-3H-spiro[isobenzofuran-1,2'-pyran]-3'-ol 

Relevant articles and documents

FLOW REACTION PROCESS FOR MANUFACTURE OF BORON-CONTAINING AGROCHEMICALS

The present invention relates to methods of preparing benzoxaboroles. Benzoxaborole compounds have shown promise as antimicrobial agents, especially against fungal pathogens. The invention also relates to compositions of acyclic alkoxy boronic acid esters as intermediates, and continuous flow processes of mixing the intermediates with organomagnesium, magnesium, or organolithium reagents to form the desired benzoxaboroles.

Copper-Catalyzed Aerobic Oxidative Cyclization Cascade to Construct Bridged Skeletons: Total Synthesis of (?)-Suaveoline

Based on the discovery of copper-catalyzed cyclopropanol ring-opening addition to iminium ions, an unprecedented catalytic aerobic C?H oxidation/cyclopropanol cyclization cascade using CuCl2 as the multifunctional catalyst and air as the oxidant was developed to construct the azabicyclo[3.3.1]nonane skeleton, which is widespread in natural products and medicines. Using this method, concise asymmetric total synthesis of the indole alkaloid (?)-suaveoline was achieved. This study not only provides an efficient, low-cost, and environmentally benign method for constructing such bridged frameworks, but also enriches the realm of cyclopropanol chemistry and C?H functionalization.

Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans

An intermolecular addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermolecular alkyl radical addition to a carbonyl group followed by an intramolecular alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR analysis. The mechanism is investigated by KIE experiments and control experiments. This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.