606939-75-7

Basic information

• Product Name: ethyl 2-hydroxy-2-phenyl-4-hexenoate
• Synonyms: ethyl 2-hydroxy-2-phenyl-4-hexenoate
• CAS NO: 606939-75-7
• Molecular Weight: 234.295
• Mol File: 606939-75-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-hydroxy-2-phenyl-4-hexenoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-hydroxy-2-phenyl-4-hexenoate(606939-75-7)
• EPA Substance Registry System: ethyl 2-hydroxy-2-phenyl-4-hexenoate(606939-75-7)

Safety Data

• Hazardous Substances Data: 606939-75-7(Hazardous Substances Data)

Upstream product

• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 5204-64-8 3-pentenoic acid 
• 64-17-5 ethanol 
• 136962-22-6 2,2-dimethyl-5-phenyl-5-(2-butenyl)-1,3-dioxolan-4-one 

Downstream Products

• 136984-50-4 (S)-2-hydroxy-2-phenyl-4-hexenoic acid 
• 137037-04-8 (R)-ethyl 2-hydroxy-2-phenyl-4-hexenoate 

Relevant articles and documents

Synthesis of Sterically Hindered α-Hydroxycarbonyls through Radical-Radical Coupling

We describe a synthetic approach to sterically hindered α-hydroxy carbonyl compounds through radical-radical coupling. An organic photoredox catalysis reaction converts an aliphatic carboxylic acid and α-ketocarbonyl to a transient alkyl radical and a persistent ketyl radical, respectively, which couple selectively based on the persistent radical effect. This protocol allows the use of primary, secondary, and tertiary aliphatic carboxylic acids to introduce various alkyl substituents onto ketone moieties of α-ketocarbonyls under mild reaction conditions.