60695-43-4

Basic information

• Product Name: {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-1-methyl-ethyl]-phenyl}-(4-fluoro-phenyl)-methanone
• CAS NO: 60695-43-4
• Molecular Weight: 421.598
• Mol File: 60695-43-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-1-methyl-ethyl]-phenyl}-(4-fluoro-phenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-1-methyl-ethyl]-phenyl}-(4-fluoro-phenyl)-methanone(60695-43-4)
• EPA Substance Registry System: {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-1-methyl-ethyl]-phenyl}-(4-fluoro-phenyl)-methanone(60695-43-4)

Safety Data

• Hazardous Substances Data: 60695-43-4(Hazardous Substances Data)

Upstream product

• 60601-82-3 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]-piperidine 
• 1194-02-1 4-fluorobenzonitrile 

Relevant articles and documents

Bulky amine analogues of ketoprofen: Potent antiinflammatory agents

Replacement of the carboxyl group of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay on rats than currently marketed nonsteroidal antiinflammatory drugs. Activity is maintained on reduction of these 2-(3-benzoylphenyl)propyl bulky amines to the corresponding alcohols or methylene analogues, on conversion of the ketone function to a primary amine or oxime, and on introduction of a 4-halo substituent (Cl or F) on the terminal aromatic ring. Removal of the α-CH3 group greatly reduces the antiinflammatory activity of the series. These compounds have been synthesized by the reductive amination of 2-(3-bromophenyl)propionaldehyde with the respective amine followed by lithiation of this product and condensation with the appropriate benzonitrile.