60695-82-1Relevant academic research and scientific papers
Decarboxylative Bromination of Sterically Hindered Carboxylic Acids with Hypervalent Iodine(III) Reagents
Kanazawa, Junichiro,Koyamada, Kenta,Miyamoto, Kazunori,Uchiyama, Masanobu,Watanabe, Ayumi
supporting information, p. 1328 - 1334 (2020/08/14)
Sterically hindered three-dimensional (3D) alkyl halides are promising precursors for various reactions; however, they are difficult to synthesize via conventional reactions. We present an efficient and practical method for decarboxylative bromination of sterically hindered 3D aliphatic carboxylic acids using commercially available (diacetoxyiodo)benzene and potassium bromide, one of the most stable and cheapest bromine sources in nature. The present method features a metal-free/Br2-free system, mild reaction conditions, one-pot operation under air at room temperature, wide functional group compatibility, and gram-scale synthetic capability. This highly efficient reaction cleanly converts a broad range of carboxylic acids, the most inexpensive and readily available sources of highly strained/naturally occurring/drug-related scaffolds, into the corresponding alkyl bromides in good to high yields.
Formal intramolecular photoredox chemistry of meta-substituted benzophenones
Mitchell, Devin,Lukeman, Matthew,Lehnherr, Dan,Wan, Peter
, p. 3387 - 3389 (2007/10/03)
(Chemical Equation Presented) Photolysis of 3-(hydroxymethyl)benzophenone (1) in aqueous solution (pH -4 M) conditions. Evidence suggests that the highly efficient (Φ ～ 0.6) reaction involves a unimolecular mechanism and an overall formal intramolecular photoredox process, which requires electronic communication between the 1,3-positions of the benzene ring, an unprecedented example of the photochemical meta effect. The photoredox reaction was not observed in organic solvents, where only photoreduction of the benzophenone moiety was observed.
Method for preparing 3-ethylbenzophenone
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, (2008/06/13)
The present invention provides a method for preparing 3-ethylbenzophenone in a high purity which comprises the steps of alkylating benzene with ethylene with the aid of an alkylating catalyst to obtain an alkylated product composed mainly of unreacted benzene, ethylbenzene, polyethylbenzenes and heavier by-products; subjecting the alkylated product to distillation in order to recover therefrom a fraction which has a temperature range of boiling points within the range of 275° to 310° C. (in terms of atmospheric pressure); dehydrogenating the recovered fraction at a reaction temperature within the range of 200° to 700° C. in the presence of a dehydrogenating catalyst; oxidizing the dehydrogenated fraction in a liquid phase; and performing distillation to recover therefrom 3-ethylbenzophenone represented by the formula: STR1
Method for preparing 3-ethylbenzophenone
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, (2008/06/13)
The present invention provides a method for preparing 3-ethylbenzophenone in a high purity which comprises the steps of alkylating benzene with ethylene in the presence of an alkylating catalyst to obtain an alkylated product composed mainly of unreacted benzene, ethylbenzene, polyethylbenzenes and heavier substances; subjecting the alkylated product to rectification in order to recover therefrom a fraction which has a temperature range of boiling points within the range of 275° to 310° C. (in terms of atmospheric pressure); heating the recovered fraction together with a mixture of nitric acid and water; carrying out purification, if necessary; and performing distillation to recover therefrom 3-ethylbenzophenone represented by the formula (I): STR1
1,1-(3-ethylphenyl)phenylethylene and method for preparing it
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, (2008/06/13)
The present invention is concerned with a novel intermediate 1,1-(3-ethylphenyl)phenylethylene represented by the formula (I) and its manufacturing method, and according to the present invention, Ketoprofen can be synthesized at a low cost and in a high y
