60696-62-0

Basic information

• Product Name: norcholic acid
• Synonyms: (3α,5β,7α,12α)-3,7,12-Trihydroxy-24-norcholan-23-oic Acid;24-Norcholic Acid;3α,7α,12α-Trihydroxy- 23-nor-5β-cholanic Acid;3α,7α,12α-Trihydroxy-24-nor-5β-cholan-23-oic Acid
• CAS NO: 60696-62-0
• Molecular Formula: C₂₃H₃₈O₅
• Molecular Weight: 394.548
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 60696-62-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 183.5 °C
• Boiling Point: 574.5°C at 760 mmHg
• Flash Point: 315.3°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 1.36E-15mmHg at 25°C
• Refractive Index: 1.562
• PKA: 4.71±0.10(Predicted)
• CAS DataBase Reference: norcholic acid(CAS DataBase Reference)
• NIST Chemistry Reference: norcholic acid(60696-62-0)
• EPA Substance Registry System: norcholic acid(60696-62-0)

Safety Data

• Hazardous Substances Data: 60696-62-0(Hazardous Substances Data)

Usage

Chemical Properties

Light Tan to Pale Yellow Solid

Uses

A novel bile acid, an analogue of Cholic acid (C432600).

InChI:InChI=1/C23H38O5/c1-12(8-20(27)28)15-4-5-16-21-17(11-19(26)23(15,16)3)22(2)7-6-14(24)9-13(22)10-18(21)25/h12-19,21,24-26H,4-11H2,1-3H3,(H,27,28)/t12?,13-,14+,15+,16?,17?,18+,19-,21?,22-,23+/m0/s1

Upstream product

• 51102-05-7 3α,7α,12α-triacetoxy-24,24-diphenyl-5β-chol-23-ene 
• 1448-36-8 methyl cholate 
• 61881-03-6 24.24-diphenyl-5β-cholanetetrol-(3α.7α.12α.24) 
• 51102-08-0 3α,7α,12α-triacetoxy-24-nor-5β-cholan-23-oic acid 

Downstream Products

• 68832-44-0 5β-cholestane-3α,7α,12α,23R-tetrol 
• 141540-97-8 sodium 3α,7α,12α-trihydroxy-24-nor-5β-cholane-23-sulfonate 
• 141417-54-1 23-p-toluenesulfoxy-24-nor-5β-cholane-3α,7α,12α-triol 
• 190513-05-4 (3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-10,13-Dimethyl-17-[(S)-1-methyl-2-(triphenyl-λ⁵-phosphanylidene)-ethyl]-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triol 
• 64595-24-0 methyl 7α,12α-diacetoxy-3α-hydroxy-24-nor-5β-cholan-23-oate 
• 198016-20-5 pentafluorophenyl 3β-[bis(butoxycarbonyl)methyl]-3α-[[[p-(tert-butoxycarbonyl)amino]methyl]phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate 
• 198016-19-2 methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[[[p-(tert-butoxycarbonyl)amino]methyl]phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate 
• 198016-16-9 methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate 
• 198016-18-1 methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-azidomethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate 
• 198016-17-0 methyl 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-hydroxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-23-oate 

Relevant articles and documents

A convenient synthesis of dinorbile acids: Oxidative hydrolysis of norbile acid nitriles

We report a convenient method for the synthesis of dinorbile acids (23,24-dinor-5β-cholan-22-oic acids, pregnane-20-carboxylic acids) in fair to good yields from norbile acid nitriles in one step by oxidative hydrolysis with oxygen in the presence of potassium-t-butoxide. The method results in stepwise overall removal of two carbon atoms in bile acid side chains in two steps. Dinorbile acids corresponding to several common bile acids have been prepared and their structures confirmed by spectroscopic methods. This simple method for synthesis of dinorbile acids may facilitate their study metabolically.